Hi, I just wanted to check if Open Targets includes affinity constants (Ki, Kd) either experimentally determined or predicted? If so, how/where can I found this data? Many thanks,
Andrea
Hi @Amsanta and welcome to our Community!
we provide information on the mechanism of action by which drugs interact with their targets, but specific affinity data is not included.
For such affinity metrics, I’d suggest you go to ChEMBL. It has a large database of binding affinities, including Ki and Kd values, which can complement the information you find in Open Targets.
We have been looking at their assay data to infer potential interactions with other targets not explicitly listed as drug targets, but this is still in an exploratory phase. If you need help understanding the data in ChEMBL, you can reach out to them in their help desk.
Thank you!
Irene
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