I am a project lead on an OTAR study at Sanger. We have been exploring the drug-target database that links bioactive molecules (ChEMBL ids) to candidate target genes.
A couple of questions:
What is the difference between the “linkedTargets” column in the “molecule” table (
rsync -rpltvz --delete rsync.ebi.ac.uk::pub/databases/opentargets/platform/21.06/output/etl/json/molecule .) compared to the “targets” column of the “mechanismOfAction” table (
rsync -rpltvz --delete rsync.ebi.ac.uk::pub/databases/opentargets/platform/21.04/output/etl/json/mechanismOfAction .)?
Is there documentation for how these gene targets are determined?
I thought I would post my questions here as others may have similar questions in the future.
Many thanks for your time and help.