Filtration of the data ingested into the Open Targets Platform from Open Targets Genetics

[hcornu]

Hi @tzukuo! Someone else had the same question, and you might find this response helpful:

How does the Open Targets Platform process data from Open Targets Genetics?

Hi Pankaj, Welcome to the OpenTargets Community! On the OT Genetics Portal gene page you will found all the GWAS loci that could be linked to the gene TREM2. If you apply a filter on the trait and narrow down the list to loci for Alzheimer disease (trait column drop-down filter), you’ll get only two of them, where the l2g score is 0.012 and 0.016, which are below the 0.05 threshold we apply to generate disease/target evidence for the Platform. If you are looking for stronger l2g association l…