Hi Pankaj,
Welcome to the OpenTargets Community! On the OT Genetics Portal gene page you will found all the GWAS loci that could be linked to the gene TREM2.
If you apply a filter on the trait and narrow down the list to loci for Alzheimer disease (trait column drop-down filter), you’ll get only two of them, where the l2g score is 0.012 and 0.016, which are below the 0.05 threshold we apply to generate disease/target evidence for the Platform.
If you are looking for stronger l2g association like from Wojcik GL et al, where the locus was discovered for C-reactive protein measurement and the l2g score is 0.76, you’ll find the association in the relevant evidence page of the Platform.
Please let me know if my comment didn’t fully address your concern. And please don’t hesitate contacting us with further questions.
Best,
Daniel