UKB-PPP pQTL data online

Dear Team,

Exciting UKB-PPP pQTL is online. I am wondering what’s the plan to engage the data to the platform? Do we have a list how many pQTLs have been included in the open targets platform? Thanks.

The UK Biobank Pharma Proteomics Project (UKB-PPP) is a collaboration between the UK Biobank (UKB) and thirteen biopharmaceutical companies characterising the plasma proteomic profiles of 54,306 UKB participants. Here, we describe results from the first phase of UKB-PPP, including protein quantitative trait loci (pQTL) mapping of 1,463 proteins that identifies 10,248 primary genetic associations, of which 85% are newly discovered. We also identify independent secondary associations in 92% of cis and 29% of trans loci, expanding the catalogue of genetic instruments for downstream analyses.

Genetic regulation of the human plasma proteome in 54,306 UK Biobank participants | bioRxiv

Unfortunately, the data is not available yet, but we are keeping a close look at it.

Current pQTL studies in Genetics Portal are:

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