Are you considering implementing two-sample MR?

Dear Team,

I am wondering why Mendelian Randomization (two-sample MR) is not implemented in Open Targets platform which will be very helpful for target identification and validation.



Hi @Shicheng_Guo. After some internal discussions, I can report the following. Experiments using mendelian randomisation approach have indeed been tried on the Open Targets platform data. However, the current results aren’t finalised and reliable enough to be used for production. Currently, this effort is being taken over by a team at Sanger Institute. Once they’re done with this, it will be incorporated into the Platform. However, at this moment we don’t have an estimate for when this will happen

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