We have just released the latest update to the Open Targets Platform — 25.09.
Key stats
| Metric | Count |
|---|---|
| Targets | 78,726 |
| Diseases | 39,530 |
| Drugs | 18,119 |
| Evidence | 30,396,274 |
| Associations | 10,989,518 |
Number of credible sets
| Study Type | Count |
|---|---|
| GWAS | 817,738 |
| sQTL | 223,500 |
| pQTL | 33,731 |
| tuQTL | 384,852 |
| eQTL | 1,349,478 |
| sceQTL | 52,744 |
Number of unique studies with at least one credible set: 40,288
Number of unique biosampleIDs (number of tissues/cell-types) from molQTLs: 98
Evidence metrics for this release:
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3,418,392 genetic evidence from European Variation Archive (EVA)
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1,753,850 GWAS credible sets from GWAS Catalog, FinnGen through Gentropy
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3,307 genetic evidence from Gene2Phenotype
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34,079 genetic evidence from the Genomics England PanelApp
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3,047 genetic evidence from ClinGen
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6,243 genetic evidence from Orphanet
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38,181 genetic evidence from Gene burden
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21,685 genetic evidence from CRISPRBrain
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6,744 genetic evidence from UniProt Literature
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9,117 somatic evidence from European Variation Archive (EVA)
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4,223 somatic evidence from intOGen
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91,572 somatic evidence from the Cancer Gene Census
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33,047 somatic evidence from Uniprot
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573,103 drug evidence from ChEMBL
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237,329 expression evidence from Expression Atlas
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10,188 affected pathway evidence from Reactome
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72,459 affected pathway evidence from SLAPenrich
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378 affected pathway evidence from PROGENy
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390 systems biology evidence from SysBio
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1,300 somatic evidence from the Cancer Genome Interpreter
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517 CRISPR-Cas9 (Cancer Cell Lines) evidence from Pacini et al. (2024)
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1,196,054 mouse model evidence from IMPC
22,881,069 scientific literature evidence from co-occurrence mining in Europe PMC
For more details and numbers, read the 25.09 blog post.