We have just released the latest update to the Open Targets Platform — 25.06.
We’re trying something new: tomorrow at 3pm UK time, join our walkthrough and Q&A session on LinkedIn. The team will showcase the new features and data in this release, and then will answer your questions about the release and the Platform. See you there!
Key stats
| Metric | Count |
|---|---|
| Targets | 78,726 |
| Diseases | 38,959 |
| Drugs | 18,081 |
| Evidence | 29,602,753 |
| Associations | 10,563,905 |
Number of credible sets
| Study Type | Count |
|---|---|
| GWAS | 789,453 |
| sQTL | 223,500 |
| pQTL | 33,731 |
| tuQTL | 384,852 |
| eQTL | 1,349,478 |
| sceQTL | 52,744 |
- Number of unique studies with at least one credible set: 39282
- Number of unique biosampleIDs (number of tissues/cell-types) from molQTLs: 98
Evidence metrics for this release
- 3,553,201 genetic evidence from European Variation Archive (EVA)
- 1,560,570 GWAS credible sets from GWAS Catalog, FinnGen through Gentropy
- 3,304 genetic evidence from Gene2Phenotype
- 34,841 genetic evidence from the Genomics England PanelApp
- 3,100 genetic evidence from ClinGen
- 6,301 genetic evidence from Orphanet
- 38,223 genetic evidence from Gene burden
- 21,700 genetic evidence from CRISPRBrain
- 6,744 genetic evidence from UniProt Literature
- 9,830 somatic evidence from European Variation Archive (EVA)
- 4,224 somatic evidence from intOGen
- 82,754 somatic evidence from the Cancer Gene Census
- 33,047 somatic evidence from Uniprot
- 573,103 drug evidence from ChEMBL
- 229,398 expression evidence from Expression Atlas
- 10,166 affected pathway evidence from Reactome
- 72,405 affected pathway evidence from SLAPenrich
- 378 affected pathway evidence from PROGENy
- 390 systems biology evidence from SysBio
- 1,300 somatic evidence from the Cancer Genome Interpreter
- 517 CRISPR-Cas9 (Cancer Cell Lines) evidence from Pacini et al. (2024)
- 1,188,863 mouse model evidence from IMPC
- 22,168,394 scientific literature evidence from co-occurrence mining in Europe PMC
For more details and numbers, read the 25.06 blog post.