We have just released the latest update to the Open Targets Platform — 23.09.
Release metrics
This release integrates 16,232,046 evidence strings to build 7,922,844 target-disease associations between 25,209 diseases and 62,733 targets from the following 23 public resources:
- 2,895,491 genetic evidence from European Variation Archive (EVA)
- 781,862 genetic evidence from Open Targets Genetics
- 3,011 genetic evidence from Gene2Phenotype
- 31,394 genetic evidence from the Genomics England PanelApp
- 2,183 genetic evidence from ClinGen
- 6,342 genetic evidence from Orphanet
- 27,381 genetic evidence from Gene burden
- 24,907 genetic evidence from CRISPRBrain
- 4,135 genetic evidence from UniProt Literature
- 17,099 somatic evidence from European Variation Archive (EVA)
- 4,359 somatic evidence from intOGen
- 76,289 somatic evidence from the Cancer Gene Census
- 26,258 somatic evidence from Uniprot
- 625,734 drug evidence from ChEMBL
- 230,893 expression evidence from Expression Atlas
- 10,095 affected pathway evidence from Reactome
- 72,440 affected pathway evidence from SLAPenrich
- 378 affected pathway evidence from PROGENy
- 389 systems biology evidence from SysBio
- 1,300 somatic evidence from the Cancer Genome Interpreter
- 1,838 CRISPR-Cas9 (Cancer Cell Lines) evidence from Behan et al. 2019
- 1,032,845 mouse model evidence from IMPC
- 10,355,423 scientific literature evidence from co-occurence mining in Europe PMC
Additionally, the Platform now allows users to explore data on 17,096 drugs.
For more details, read the 23.09 blog post.