24.03 Platform release now live!

[hcornu]

We have just released the latest update to the Open Targets Platform — 24.03.

Key highlights for this release:

This release integrates 17,317,290 evidence strings to build 7,802,260 target-disease associations between 25,817 diseases and 63,226 targets from the following 23 public resources:

• 2,999,652 genetic evidence from European Variation Archive (EVA)
• 781,437 genetic evidence from Open Targets Genetics
• 3,118 genetic evidence from Gene2Phenotype
• 31,921 genetic evidence from the Genomics England PanelApp
• 2,416 genetic evidence from ClinGen
• 6,473 genetic evidence from Orphanet
• 27,381 genetic evidence from Gene burden
• 21,726 genetic evidence from CRISPRBrain
• 4,168 genetic evidence from UniProt Literature
• 16,927 somatic evidence from European Variation Archive (EVA)
• 4,359 somatic evidence from intOGen
• 82,754 somatic evidence from the Cancer Gene Census
• 26,217 somatic evidence from Uniprot
• 624,491 drug evidence from ChEMBL
• 230,182 expression evidence from Expression Atlas
• 10,160 affected pathway evidence from Reactome
• 72,441 affected pathway evidence from SLAPenrich
• 378 affected pathway evidence from PROGENy
• 389 systems biology evidence from SysBio
• 1,300 somatic evidence from the Cancer Genome Interpreter
• 517 CRISPR-Cas9 (Cancer Cell Lines) evidence from Pacini et al. (2024)
• 1,082,451 mouse model evidence from IMPC
• 11,286,432 scientific literature evidence from co-occurrence mining in Europe PMC

Additionally, the Platform now allows users to explore data on 17,111 drugs.

For more details, read the 24.03 blog post.

[Shicheng_Guo]

Really impressive achievement!! Congratulations team!!

[jhju]

Thank you very much for all the work that went in to make this update happen. OpenTargets has been by far the most useful public data resource. You guys are setting a great example.

Quick question regarding the 24.03 release, do you have an estimate on when the data on BigQuery will be updated as well? The release version seems to still be 23.12. Thank you!

Update: noticed that there are 2 tables that can be used open-targets-prod.platform.ot_release and bigquery-public-data.open_targets_platform.ot_release the first one shows the updated release and the second one shows the previous version. I’ll use the first one as noted in the documentation.