Just in time for the summer, we have released the latest version of the Open Targets Platform — 21.06. Thanks to the concurrent release of the Open Targets Genetics Portal, we have exciting new data from FinnGen, a public-private partnership to identify genotype-phenotype correlations in the Finnish population, as well as from the EBI’s GWAS Catalog. We have also ingested new target-disease associations for rare diseases from Orphanet.
This release integrates 13,267,236 evidence strings to build 11,755,362 target-disease associations between 18,507 diseases and 60,606 targets from the following 21 public resources:
- 855,569 genetic evidence from European Variation Archive (EVA)
- 608,320 genetic evidence from Open Targets Genetics Portal
- 2,506 genetic evidence from Gene2Phenotype
- 19,322 genetic evidence from the Genomics England PanelApp
- 1,309 genetic evidence from ClinGen
- 5,736 genetic evidence from Orphanet
- 183,064 genetic evidence from the PheWAS catalog
- 5,322 genetic evidence from UniProt Literature
- 11,589 somatic evidence from European Variation Archive (EVA)
- 3,141 somatic evidence from intOGen
- 63,311 somatic evidence from the Cancer Gene Census
- 34,001 somatic evidence from Uniprot
- 529,149 drug evidence from ChEMBL
- 225,933 expression evidence from Expression Atlas
- 9,673 affected pathway evidence from Reactome
- 72,369 affected pathway evidence from SLAPenrich
- 378 affected pathway evidence from PROGENy
- 389 systems biology evidence from SysBio
- 1,846 CRISPR-Cas9 (Cancer Cell Lines) evidence from Behan et al. 2019
- 718,250 mouse model evidence from PhenoDigm
- 9,916,059 scientific literature evidence from co-occurence mining in Europe PMC
Key highlights for this release:
- This latest release integrates the latest data from the Open Targets Genetics Portal, including data from FinnGen and full summary statistics from the GWAS Catalog;
- It also includes a new data source: Orphanet, allowing us to feature over 700 target-disease associations unique to that dataset.
For more details, read the 21.06 release blog post.