Hello Open Targets Community!
One of our users has reported issues with the colocalisation data in our latest Genetics release (v6). Our team have reviewed the datasets and pipelines and we have identified the issue:
Between 10% - 30% of GWAS colocalisations are showing incorrect values (both GWAS-GWAS colocs, and GWAS-QTL colocs). In these cases, we have most often been reporting a low colocalisation probability where a higher one should be shown. This primarily affects regions where a GWAS or QTL study has multiple signals within 1 Mb of each other.
We are currently preparing for an update and the plan is to release it during w/c 7 February 2022.
If you have any questions or concerns, please comment below or send us an email at email@example.com.