# Where to find tractability\_buckets file in the latest version, for example, version:22.11?

**URL:** <https://community.opentargets.org/t/where-to-find-tractability-buckets-file-in-the-latest-version-for-example-version-22-11/922>\
**Category:** Data downloads\
**Tags:** data, ftp\
**Created:** [14 January 2023 00:20 UTC](https://community.opentargets.org/t/where-to-find-tractability-buckets-file-in-the-latest-version-for-example-version-22-11/922 "2023-01-14T00:20:46Z")\
**Posts on this page:** 2\
**Page:** 1

<div class="post-metadata">

**Author:** ![Shicheng\_Guo](https://dub1.discourse-cdn.com/flex017/user_avatar/community.opentargets.org/shicheng_guo/32/217_2.png) [@Shicheng\_Guo](https://community.opentargets.org/u/Shicheng_Guo)\
**Post date:** [14 January 2023 00:20 UTC](https://community.opentargets.org/t/where-to-find-tractability-buckets-file-in-the-latest-version-for-example-version-22-11/922/1 "2023-01-14T00:20:46Z")

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Dear Team,

Where to find tractability\_buckets file in the latest version, for example, version:22.11?

[http://ftp.ebi.ac.uk/pub/databases/opentargets/platform/latest/input/](http://ftp.ebi.ac.uk/pub/databases/opentargets/platform/latest/input/)

[tractability\_buckets-2021-03-08.tsv](http://ftp.ebi.ac.uk/pub/databases/opentargets/platform/21.04/input/annotation-files/tractability_buckets-2021-03-08.tsv)

Meanwhile, do we have a webpage for the details for each column name? for example:

[1] “ensembl\_gene\_id” “symbol”  
[3] “accession” “Entry”  
[5] “name” “Protein”  
[7] “names” “IDG\_family”  
[9] “IDG\_dtoclass” “IDG\_tdl”  
[11] “IDG\_fam” “GO\_BioProcess”  
[13] “GO\_MolFunction” “SM\_B1\_Approved”  
[15] “Drug” “SM\_B2\_Advanced”  
[17] “Clinical” “SM\_B3\_Phase”  
[19] “1” “Clinical\_1”  
[21] “SM\_B4\_Structure” “with”  
[23] “Ligand” “SM\_B5\_High-Quality”  
[25] “Ligand\_1” “SM\_B6\_High-Quality”  
[27] “Pocket” “SM\_B7\_Med-Quality”  
[29] “Pocket\_1” “SM\_B8\_Druggable”  
[31] “Family” “Bucket\_sum\_sm”  
[33] “Top\_bucket\_sm” “drug\_chembl\_ids\_sm”  
[35] “drug\_names\_sm” “clinical\_phases\_sm”  
[37] “PDB\_Known\_Ligand” “PDB\_other”  
[39] “High\_Quality\_ChEMBL\_compounds” “DrugEBIlity\_score”  
[41] “Small\_Molecule\_Druggable\_Genome\_Member” “Category\_sm”  
[43] “Clinical\_Precedence\_sm” “Discovery\_Precedence\_sm”  
[45] “Predicted\_Tractable\_sm” “drug\_names\_dict\_sm”  
[47] “clinical\_phases\_dict\_sm” “AB\_B1\_Approved”  
[49] “Drug\_1” “AB\_B2\_Advanced”  
[51] “Clinical\_2” “AB\_B3\_Phase”  
[53] “1\_1” “Clinical\_3”  
[55] “AB\_B4\_UniProt” “loc”  
[57] “high” “conf”  
[59] “AB\_B5\_GO” “CC”  
[61] “high\_1” “conf\_1”  
[63] “AB\_B6\_UniProt” “loc\_1”  
[65] “med” “conf\_2”  
[67] “AB\_B7\_UniProt” “SigP”  
[69] “or” “TMHMM”  
[71] “AB\_B8\_GO” “CC\_1”  
[73] “med\_1” “conf\_3”  
[75] “AB\_B9\_Human” “Protein\_1”  
[77] “Atlas” “loc\_2”  
[79] “Bucket\_sum\_ab” “Top\_bucket\_ab”  
[81] “drug\_chembl\_ids\_ab” “drug\_names\_ab”  
[83] “clinical\_phases\_ab” “Uniprot\_high\_conf\_loc”  
[85] “GO\_high\_conf\_loc” “Uniprot\_med\_conf\_loc”  
[87] “GO\_med\_conf\_loc” “Gene”  
[89] “ontology” “(cellular”  
[91] “component)” “Transmembrane”  
[93] “Signal\_peptide” “HPA\_main\_location”  
[95] “Clinical\_Precedence\_ab” “Predicted\_Tractable\_ab\_High\_confidence”  
[97] “Predicted\_Tractable\_ab\_Medium\_to\_low\_confidence” “Category\_ab”  
[99] “drug\_names\_dict\_ab” “clinical\_phases\_dict\_ab”  
[101] “PR\_B1\_Approved” “Drug\_2”  
[103] “PR\_B2\_Advanced” “Clinical\_4”  
[105] “PR\_B3\_Phase” “1\_2”  
[107] “Clinical\_5” “PR\_B4\_Literature”  
[109] “PR\_B5\_UniProt” “Ubiquitination”  
[111] “PR\_B6\_Database” “Ubiquitination\_1”  
[113] “PR\_B7\_Half-life” “Data”  
[115] “PR\_B8\_Small” “Molecule”  
[117] “Binder” “Bucket\_sum\_PROTAC”  
[119] “Top\_bucket\_PROTAC” “PR\_locB\_Location”  
[121] “Score” “mentioned\_in\_PROTAC\_literature”  
[123] “literature\_count\_PROTAC” “pub\_id”  
[125] “full\_id” “title”  
[127] “Max\_halflife” “Min\_halflife”  
[129] “Uniprot\_keyword” “Uniprot\_PTM”  
[131] “Uniprot\_CrossLink” “Ub\_PhosphoSitePlus”  
[133] “Ub\_mUbiSiDa\_2013” “number\_of\_ubiquitination\_sites”  
[135] “Bcell\_mean” “NKcell\_mean”  
[137] “Hepatocytes\_mean” “MouseNeuorons\_mean”  
[139] “count\_compound\_chembl\_ids\_PROTAC” “Clinical\_Precedence\_PROTAC”  
[141] “Literature\_Precedence\_PROTAC” “Discovery\_Opportunity\_PROTAC”  
[143] “Category\_PROTAC” “OC\_B1\_Approved”  
[145] “Drug\_3” “OC\_B2\_Advanced”  
[147] “Clinical\_6” “OC\_B3\_Phase”  
[149] “1\_3” “Clinical\_7”  
[151] “Bucket\_sum\_othercl” “Top\_bucket\_othercl”  
[153] “drug\_chembl\_ids\_othercl” “drug\_names\_othercl”  
[155] “clinical\_phases\_othercl” “Clinical\_Precedence\_othercl”  
[157] “Category\_othercl” “drug\_names\_dict\_othercl”  
[159] “clinical\_phases\_dict\_othercl”

Thanks.

Shicheng

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<div class="post-metadata">

**Author:** ![irene](https://dub1.discourse-cdn.com/flex017/user_avatar/community.opentargets.org/irene/32/50_2.png) [@irene](https://community.opentargets.org/u/irene)\
**Post date:** [16 January 2023 18:07 UTC](https://community.opentargets.org/t/where-to-find-tractability-buckets-file-in-the-latest-version-for-example-version-22-11/922/2 "2023-01-16T18:07:19Z")

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Hello!

If you want to investigate the tractability raw assessments, this data is made available through our FTP. For example, the target annotation of the latest release is based on this file: [http://ftp.ebi.ac.uk/pub/databases/opentargets/platform/latest/input/target-inputs/tractability/tractability.tsv](http://ftp.ebi.ac.uk/pub/databases/opentargets/platform/latest/input/target-inputs/tractability/tractability.tsv)

To know more about the provenance of each of those columns, the best place to look at is the source code at [tractability\_pipeline\_v2/README.md at 1712a5e001bc5daedf912f2ed60ca8a7bf97b081 · chembl/tractability\_pipeline\_v2 · GitHub](https://github.com/chembl/tractability_pipeline_v2/blob/1712a5e001bc5daedf912f2ed60ca8a7bf97b081/README.md)

Here you can see how each of the buckets are assessed. Please let us know if you have further questions!

Best,  
Irene