# Tractability - Half-life Data

**URL:** <https://community.opentargets.org/t/tractability-half-life-data/1483>\
**Category:** General\
**Tags:** ot-platform\
**Created:** [16 July 2024 16:06 UTC](https://community.opentargets.org/t/tractability-half-life-data/1483 "2024-07-16T16:06:26Z")\
**Posts on this page:** 2\
**Page:** 1

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**Author:** ![Shicheng\_Guo](https://dub1.discourse-cdn.com/flex017/user_avatar/community.opentargets.org/shicheng_guo/32/217_2.png) [@Shicheng\_Guo](https://community.opentargets.org/u/Shicheng_Guo)\
**Post date:** [16 July 2024 16:06 UTC](https://community.opentargets.org/t/tractability-half-life-data/1483/1 "2024-07-16T16:06:26Z")

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Dear Team,

I notice we have a Half-life Data information in Tractability session. I am wondering where we can find more information about “Half-life Data”. Are we able to get “Half-life Data” for all the human targets?

Thanks.

Shicheng

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**Author:** ![hcornu](https://dub1.discourse-cdn.com/flex017/user_avatar/community.opentargets.org/hcornu/32/716_2.png) [@hcornu](https://community.opentargets.org/u/hcornu)\
**Post date:** [18 July 2024 09:46 UTC](https://community.opentargets.org/t/tractability-half-life-data/1483/2 "2024-07-18T09:46:52Z")

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Hi Shicheng,

The half-life assessment is derived from the PROTACtable Genome workflow, which gets the half-life assessments from [Mathieson et al.](https://www.nature.com/articles/s41467-018-03106-1). Quoting from the [PROTACtable genome paper](https://www.nature.com/articles/s41573-021-00245-x):

> The half-life data bucket (7) indicates the presence of experimental data on protein half-life. Knowledge of the rate at which a protein is naturally turned over is relevant to the use of a PROTAC designed to artificially accelerate this process, as a very short protein half-life may limit the effective utility of a PROTAC compound. A recent study from Mathieson et al. (see Supplementary Data 2 in their paper) describes the use of SILAC-based proteomics to determine protein half-lives ranging from 10 to \>1,000 h in a variety of cell types (B cells, natural killer cells, hepatocytes, monocytes and mouse embryonic neurons). In our PROTAC workflow, we capture both minimal and maximal half-lives across the different cell types studied.