# Subcellular location and species in the 'Targets' data downloads dataset **URL:** \ **Category:** General\ **Tags:** data\ **Created:** [13 January 2023 14:41 UTC](https://community.opentargets.org/t/subcellular-location-and-species-in-the-targets-data-downloads-dataset/921 "2023-01-13T14:41:12Z")\ **Posts on this page:** 5\ **Page:** 1
**Author:** ![teekay](https://avatars.discourse-cdn.com/v4/letter/t/898d66/32.png) [@teekay](https://community.opentargets.org/u/teekay)\ **Post date:** [13 January 2023 14:41 UTC](https://community.opentargets.org/t/subcellular-location-and-species-in-the-targets-data-downloads-dataset/921/1 "2023-01-13T14:41:12Z")
Hello, I have two questions on the “Targets” dataset (listed below) and would appreciate any insights anyone may have! Thanks. 1. Why is a subcellular location included for every entry separate from a Cellular Component GO term? 2. Are all of the entries (genes, targets) human-specific? I noticed that for every entry there was a “Species” specification, it seemed to fall under the “Homolog” category, and I was wondering if someone could explain to me if species is indeed listed under Homolog and what this means. I would just like to obtain human targets. ---
**Author:** ![ochoa](https://dub1.discourse-cdn.com/flex017/user_avatar/community.opentargets.org/ochoa/32/189_2.png) [@ochoa](https://community.opentargets.org/u/ochoa)\ **Post date:** [16 January 2023 13:32 UTC](https://community.opentargets.org/t/subcellular-location-and-species-in-the-targets-data-downloads-dataset/921/2 "2023-01-16T13:32:12Z")
Hi teekay, > 1. Why is a subcellular location included for every entry separate from a Cellular Component GO term? At the moment, subcellular location does not include the Gene Ontology Cellular Component data, which you can find in the Gene Ontology (GO) widget. There are differences in the way information is curated in Uniprot and HPA as opposed to GO. The most important difference is that GO does not aim to assess what’s the likely location of a particular gene product. Instead, it reports any evidence of the gene product being located in a particular subsystem. Some unlikely locations can occur as a consequence of this as discussed in previous posts. > [@Antibodies tractability pipe and results issues](https://community.opentargets.org/t/antibodies-tracktability-pipe-and-results-issues/349/6): > > This is the logic the team who developed the tractability pipeline used. I would agree with this formula, based on how the 2 resources are defined. Gene Ontology would not produce an assessment of the most likely subcellular location of a protein. It just keeps adding annotations based on the availability of evidence. In BRCA1 for example, you can find Gene ontology evidence pointing to the cytoplasm as a cellular component (an unlikely location). Uniprot… > 1. Are all of the entries (genes, targets) human-specific? I noticed that for every entry there was a “Species” specification, it seemed to fall under the “Homolog” category, and I was wondering if someone could explain to me if species is indeed listed under Homolog and what this means. I would just like to obtain human targets. All entries in the `targets` dataset are human genes as described in the [documentation](https://platform-docs.opentargets.org/target). In the `Homolog` column you can find comparative genomics information retrieved from Ensembl Compara. This information will only be useful in case you want to find targets in other species with the same evolutionary origin as your human target. I hope this helps David ---
**Author:** ![koryclick](https://dub1.discourse-cdn.com/flex017/user_avatar/community.opentargets.org/koryclick/32/577_2.png) [@koryclick](https://community.opentargets.org/u/koryclick)\ **Post date:** [4 February 2025 17:00 UTC](https://community.opentargets.org/t/subcellular-location-and-species-in-the-targets-data-downloads-dataset/921/3 "2025-02-04T17:00:59Z")
Hello! related with this topic, I see that in opentargets, it is displayed for my gene of interest, a gene ontology, and the classification (for example biological process, or cellular component). but i cannot find this information in the OT json download file hierarchies. how do you get the gene\_ontology classification term? is it through a restapi call to uniprot? ---
**Author:** ![Annalisa\_Buniello](https://dub1.discourse-cdn.com/flex017/user_avatar/community.opentargets.org/annalisa_buniello/32/426_2.png) [@Annalisa\_Buniello](https://community.opentargets.org/u/Annalisa_Buniello)\ **Post date:** [5 February 2025 17:06 UTC](https://community.opentargets.org/t/subcellular-location-and-species-in-the-targets-data-downloads-dataset/921/4 "2025-02-05T17:06:08Z")
Dear Kori, thank you for your question. You can find the go classification on our public [FTP](http://ftp.ebi.ac.uk/pub/databases/opentargets/platform/24.09/output/etl/parquet/go/). I hope this helps! Best wishes, Annalisa ---
**Author:** ![koryclick](https://dub1.discourse-cdn.com/flex017/user_avatar/community.opentargets.org/koryclick/32/577_2.png) [@koryclick](https://community.opentargets.org/u/koryclick)\ **Post date:** [5 February 2025 23:19 UTC](https://community.opentargets.org/t/subcellular-location-and-species-in-the-targets-data-downloads-dataset/921/5 "2025-02-05T23:19:32Z")
Thanks Annalisa, that folder contains the same info that the json “target\_go” or “go”. I was looking for the root and i found the answer in “goatools” . sorted!