# Overall association scoring - threshold/cut-off for solid interpretation

**URL:** <https://community.opentargets.org/t/overall-association-scoring-threshold-cut-off-for-solid-interpretation/1277>\
**Category:** General\
**Tags:** ot-platform\
**Created:** [9 November 2023 19:23 UTC](https://community.opentargets.org/t/overall-association-scoring-threshold-cut-off-for-solid-interpretation/1277 "2023-11-09T19:23:26Z")\
**Posts on this page:** 2\
**Page:** 1

<div class="post-metadata">

**Author:** ![Shicheng\_Guo](https://dub1.discourse-cdn.com/flex017/user_avatar/community.opentargets.org/shicheng_guo/32/217_2.png) [@Shicheng\_Guo](https://community.opentargets.org/u/Shicheng_Guo)\
**Post date:** [9 November 2023 19:23 UTC](https://community.opentargets.org/t/overall-association-scoring-threshold-cut-off-for-solid-interpretation/1277/1 "2023-11-09T19:23:26Z")

</div>

Dear Team,

Overall association scoring (Target to disease score) is quite useful to identify the target-disease relationship. I am wondering is there any recommended cut-off/threshold score for the downstream interpretation? eg, if the score\>0.8, we can make solid conclusion etc…

Thanks.

Shicheng

---

<div class="post-metadata">

**Author:** ![hcornu](https://dub1.discourse-cdn.com/flex017/user_avatar/community.opentargets.org/hcornu/32/716_2.png) [@hcornu](https://community.opentargets.org/u/hcornu)\
**Post date:** [13 November 2023 10:31 UTC](https://community.opentargets.org/t/overall-association-scoring-threshold-cut-off-for-solid-interpretation/1277/2 "2023-11-13T10:31:25Z")

</div>

Hi Shicheng,

Can I check whether your question is related to the Open Targets Platform or Open Targets Genetics? (The target-disease association score is a feature of the Platform, but your topic is tagged under ‘Genetics portal’, so I just want to check I’ve understood correctly.)

In the Platform, the overall Target-Disease association score is a reflection of the availability of data rather than a confidence assessment in the association. We don’t have a recommended cut-off because, for example, under-studied target-disease pairs will have low associations scores but may still be therapeutically interesting. ([More information in our documentation](https://platform-docs.opentargets.org/associations#interpreting-association-scores).)

If people on the Community would like to comment on how they use the scoring, I’d be interested to know!

Best wishes,

Helena

Edit: I have now updated the tag for this post.