# Open Targets Platform 22.04 is out now!

**URL:** https://community.opentargets.org/t/open-targets-platform-22-04-is-out-now/555
**Category:** Releases
**Created:** [28 April 2022 13:08 UTC](https://community.opentargets.org/t/open-targets-platform-22-04-is-out-now/555 "2022-04-28T13:08:31Z")
**Posts on this page:** 6
**Page:** 1

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### Author: ![hcornu](https://dub1.discourse-cdn.com/flex017/user_avatar/community.opentargets.org/hcornu/32/716_2.png) [@hcornu](https://community.opentargets.org/u/hcornu)
#### Post date: [28 April 2022 13:08 UTC](https://community.opentargets.org/t/open-targets-platform-22-04-is-out-now/555/1 "2022-04-28T13:08:31Z")

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We have just released the latest data update to the Open Targets Platform — 22.04.

## Key highlights for this release:

- New datasource: gene burden analyses from Regeneron in the GWAS Catalog and the AstraZeneca PheWAS portal
- Integration of structural variants from ClinVar
- Additional information in ChEMBL from DailyMed drug label text-mining
- NLP classification of why clinical trials stopped, which affects scoring
- New data: Gene2phenotype cardiac panel
- Also: renaming Phenodigm to IMPC, removing the PheWAS Catalog datasource

This release integrates 13,829,174 evidence strings to build 7,541,360 target-disease associations between 18,520 diseases and 61,524 targets from the following 22 public resources:

- 1,145,558 genetic evidence from [European Variation Archive (EVA)](http://www.ebi.ac.uk/eva/)
- 693,567 genetic evidence from [Open Targets Genetics Portal](https://genetics.opentargets.org/)
- 3,594 genetic evidence from [Gene2Phenotype](https://www.ebi.ac.uk/gene2phenotype)
- 35,622 genetic evidence from the[Genomics England PanelApp](https://bioinfo.extge.co.uk/crowdsourcing/PanelApp/)
- 1,636 genetic evidence from [ClinGen](https://search.clinicalgenome.org/kb/gene-validity/)
- 6,001 genetic evidence from Orphanet
- 18,715 genetic evidence from Gene burden
- 6,272 genetic evidence from [UniProt Literature](https://www.uniprot.org/)
- 11,653 somatic evidence from [European Variation Archive (EVA)](http://www.ebi.ac.uk/eva/)
- 3,299 somatic evidence from[intOGen](https://www.intogen.org/)
- 74,159 somatic evidence from the[Cancer Gene Census](http://cancer.sanger.ac.uk/census/)
- 39,419 somatic evidence from [Uniprot](http://www.uniprot.org/)
- 594,375 drug evidence from [ChEMBL](https://www.ebi.ac.uk/chembl/)
- 231,165 expression evidence from [Expression Atlas](https://www.ebi.ac.uk/gxa/home)
- 10,345 affected pathway evidence from [Reactome](https://reactome.org/)
- 72,369 affected pathway evidence from [SLAPenrich](https://saezlab.github.io/SLAPenrich/)
- 378 affected pathway evidence from [PROGENy](https://saezlab.github.io/progeny/)
- 389 systems biology evidence from [SysBio](https://saezlab.github.io/progeny/)
- 1,299 somatic evidence from the [Cancer Genome Interpreter](https://www.cancergenomeinterpreter.org/home)
- 1,846 CRISPR-Cas9 (Cancer Cell Lines) evidence from[Behan et al. 2019](https://europepmc.org/abstract/MED/30971826)
- 1,166,212 mouse model evidence from [IMPC](https://www.mousephenotype.org/)
- 9,746,463 scientific literature evidence from co-occurence mining in [Europe PMC](https://europepmc.org/)

Additionally, the Platform now allows users to explore data on 12,854 drugs.

For more details, read[the 22.04 release blog post](https://blog.opentargets.org/open-targets-platform-22-04-release/).

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### Author: ![sigven](https://dub1.discourse-cdn.com/flex017/user_avatar/community.opentargets.org/sigven/32/36_2.png) [@sigven](https://community.opentargets.org/u/sigven)
#### Post date: [29 April 2022 10:15 UTC](https://community.opentargets.org/t/open-targets-platform-22-04-is-out-now/555/2 "2022-04-29T10:15:19Z")

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Hi,  
Thanks for a new release!

However, I cannot see the 22.04 data on [http://ftp.ebi.ac.uk/pub/databases/opentargets/platform/](http://ftp.ebi.ac.uk/pub/databases/opentargets/platform/)?

regards,  
Sigve

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### Author: ![hcornu](https://dub1.discourse-cdn.com/flex017/user_avatar/community.opentargets.org/hcornu/32/716_2.png) [@hcornu](https://community.opentargets.org/u/hcornu)
#### Post date: [29 April 2022 10:30 UTC](https://community.opentargets.org/t/open-targets-platform-22-04-is-out-now/555/3 "2022-04-29T10:30:57Z")

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Hi @sigven!

It usually takes about 24 hours for the FTP files to be available after a release. Please check again this evening and let us know if you’re still having issues

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### Author: ![sigven](https://dub1.discourse-cdn.com/flex017/user_avatar/community.opentargets.org/sigven/32/36_2.png) [@sigven](https://community.opentargets.org/u/sigven)
#### Post date: [29 April 2022 10:32 UTC](https://community.opentargets.org/t/open-targets-platform-22-04-is-out-now/555/4 "2022-04-29T10:32:16Z")

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Great! Thanks for the quick feedback.

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### Author: ![hcornu](https://dub1.discourse-cdn.com/flex017/user_avatar/community.opentargets.org/hcornu/32/716_2.png) [@hcornu](https://community.opentargets.org/u/hcornu)
#### Post date: [29 April 2022 16:10 UTC](https://community.opentargets.org/t/open-targets-platform-22-04-is-out-now/555/5 "2022-04-29T16:10:53Z")

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Hi!

Just to note that this is a genuine bug, and the 22.04 files are not yet available on the FTP. We will let the Community know as soon as we have fixed this.

See also: [Availability of 22.04 files from the FTP](https://community.opentargets.org/t/availability-of-22-04-files-from-the-ftp/560)

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<div class="post-metadata">

### Author: ![sigven](https://dub1.discourse-cdn.com/flex017/user_avatar/community.opentargets.org/sigven/32/36_2.png) [@sigven](https://community.opentargets.org/u/sigven)
#### Post date: [29 April 2022 18:48 UTC](https://community.opentargets.org/t/open-targets-platform-22-04-is-out-now/555/6 "2022-04-29T18:48:06Z")

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OK, thanks for the notice.
