# mRNA tissue specificity is included or not?

**URL:** <https://community.opentargets.org/t/mrna-tissue-specificity-is-included-or-not/569>\
**Category:** Community Feedback\
**Tags:** genetics-portal\
**Created:** [2 May 2022 22:54 UTC](https://community.opentargets.org/t/mrna-tissue-specificity-is-included-or-not/569 "2022-05-02T22:54:17Z")\
**Posts on this page:** 3\
**Page:** 1

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**Author:** ![Shicheng\_Guo](https://dub1.discourse-cdn.com/flex017/user_avatar/community.opentargets.org/shicheng_guo/32/217_2.png) [@Shicheng\_Guo](https://community.opentargets.org/u/Shicheng_Guo)\
**Post date:** [2 May 2022 22:54 UTC](https://community.opentargets.org/t/mrna-tissue-specificity-is-included-or-not/569/1 "2022-05-02T22:54:17Z")

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Dear Team,

I am wondering whether mRNA expression tissue specificity index is included in the platform or not?

> **[benchmark of gene expression tissue-specificity metrics](https://academic.oup.com/bib/article/18/2/205/2562739)**
>
> Abstract. One of the major properties of genes is their expression pattern. Notably, genes are often classified as tissue specific or housekeeping. This propert

Thanks.

Shicheng

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**Author:** ![dsuveges](https://dub1.discourse-cdn.com/flex017/user_avatar/community.opentargets.org/dsuveges/32/30_2.png) [@dsuveges](https://community.opentargets.org/u/dsuveges)\
**Post date:** [4 May 2022 06:56 UTC](https://community.opentargets.org/t/mrna-tissue-specificity-is-included-or-not/569/2 "2022-05-04T06:56:12Z")

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Hi Shicheng,

Gene expression levels are kept under target annotation/baseline expression. Currently, this data is not stratified by tissue specificity, we only report the expression levels in a given tissue.

However, on the roadmap there are significant improvements of how the baseline expression is handled and presented on our platform. We are also considering means to capture tissue specificity as well. Thank you for pointing us to this paper, we’ll consider applying it. Unfortunately, at this point I cannot give you a timeline for the completion.

Best,  
Daniel.

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**Author:** ![Shicheng\_Guo](https://dub1.discourse-cdn.com/flex017/user_avatar/community.opentargets.org/shicheng_guo/32/217_2.png) [@Shicheng\_Guo](https://community.opentargets.org/u/Shicheng_Guo)\
**Post date:** [8 May 2022 21:10 UTC](https://community.opentargets.org/t/mrna-tissue-specificity-is-included-or-not/569/3 "2022-05-08T21:10:18Z")

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Thank you Daniel for the update. Tissue specificity will be quite useful and also purity of cell-of-tissue adjusted by single-cell reference data will be quite useful for the target evaluation. Hope we can have this feature soon. Shicheng