# Is all linkage presented in the 'evidence' folder direct evidence?

**URL:** https://community.opentargets.org/t/is-all-linkage-presented-in-the-evidence-folder-direct-evidence/426
**Category:** Technical Support
**Created:** [23 December 2021 00:37 UTC](https://community.opentargets.org/t/is-all-linkage-presented-in-the-evidence-folder-direct-evidence/426 "2021-12-23T00:37:36Z")
**Posts on this page:** 4
**Page:** 1

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### Author: ![mengysun](https://avatars.discourse-cdn.com/v4/letter/m/a698b9/32.png) [@mengysun](https://community.opentargets.org/u/mengysun)
#### Post date: [23 December 2021 00:37 UTC](https://community.opentargets.org/t/is-all-linkage-presented-in-the-evidence-folder-direct-evidence/426/1 "2021-12-23T00:37:36Z")

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Dear all,  
I am conducting an in-depth analysis of open-target data (I downloaded the raw data from the ftp). If I understand correctly, all the linkages (separated by data sources) in the evidence folder are direct linkages. The propagation to parental diseases were subsequently done to produce ‘indirect associations’ stored in the ‘association…Indirect’ folders, right?  
Thanks!  
Best,  
Mengyi

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### Author: ![ochoa](https://dub1.discourse-cdn.com/flex017/user_avatar/community.opentargets.org/ochoa/32/189_2.png) [@ochoa](https://community.opentargets.org/u/ochoa)
#### Post date: [23 December 2021 14:43 UTC](https://community.opentargets.org/t/is-all-linkage-presented-in-the-evidence-folder-direct-evidence/426/2 "2021-12-23T14:43:42Z")

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This is correct [mengysun](https://community.opentargets.org/u/mengysun).

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### Author: ![jasperhyp](https://dub1.discourse-cdn.com/flex017/user_avatar/community.opentargets.org/jasperhyp/32/186_2.png) [@jasperhyp](https://community.opentargets.org/u/jasperhyp)
#### Post date: [22 March 2022 21:39 UTC](https://community.opentargets.org/t/is-all-linkage-presented-in-the-evidence-folder-direct-evidence/426/3 "2022-03-22T21:39:35Z")

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Thanks for answering this! Might be dumb but where can I find the disease ontology used for the “propagation to parental diseases”?

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### Author: ![ochoa](https://dub1.discourse-cdn.com/flex017/user_avatar/community.opentargets.org/ochoa/32/189_2.png) [@ochoa](https://community.opentargets.org/u/ochoa)
#### Post date: [23 March 2022 09:41 UTC](https://community.opentargets.org/t/is-all-linkage-presented-in-the-evidence-folder-direct-evidence/426/4 "2022-03-23T09:41:33Z")

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There are no dumb questions here 😉

Open Targets used the Experimental Factor Ontology (EFO) that feeds from other biomedical ontologies.

More info:

> **[Disease or Phenotype](https://platform-docs.opentargets.org/disease-or-phenotype)**

Browse EFO:  
[https://www.ebi.ac.uk/ols/ontologies/efo](https://www.ebi.ac.uk/ols/ontologies/efo)

EFO codebase and releases:

> **[GitHub - EBISPOT/efo: Github repo for the Experimental Factor Ontology (EFO)](https://github.com/EBISPOT/efo)**
>
> Github repo for the Experimental Factor Ontology (EFO) - GitHub - EBISPOT/efo: Github repo for the Experimental Factor Ontology (EFO)