# Data source scores ot\_genetics\_portal vs L2G in final association score

**URL:** <https://community.opentargets.org/t/data-source-scores-ot-genetics-portal-vs-l2g-in-final-association-score/1421>\
**Category:** General\
**Tags:** genetics-portal\
**Created:** [8 May 2024 06:15 UTC](https://community.opentargets.org/t/data-source-scores-ot-genetics-portal-vs-l2g-in-final-association-score/1421 "2024-05-08T06:15:23Z")\
**Posts on this page:** 2\
**Page:** 1

<div class="post-metadata">

**Author:** ![gatla](https://dub1.discourse-cdn.com/flex017/user_avatar/community.opentargets.org/gatla/32/812_2.png) [@gatla](https://community.opentargets.org/u/gatla)\
**Post date:** [8 May 2024 06:15 UTC](https://community.opentargets.org/t/data-source-scores-ot-genetics-portal-vs-l2g-in-final-association-score/1421/1 "2024-05-08T06:15:23Z")

</div>

Hi,

I am wondering about _ot\_genetics\_portal_ and l2g score. Some genes that have _L2G_ score of \>0.65 has been given a score of 0.5 for _ot\_genetics\_portal_. I am wondering why is that. The gene has no other genetic evidences such as gene\_burden, genomics\_england etc etc. Does that bring down the l2g score ?

---

<div class="post-metadata">

**Author:** ![hcornu](https://dub1.discourse-cdn.com/flex017/user_avatar/community.opentargets.org/hcornu/32/716_2.png) [@hcornu](https://community.opentargets.org/u/hcornu)\
**Post date:** [8 May 2024 11:06 UTC](https://community.opentargets.org/t/data-source-scores-ot-genetics-portal-vs-l2g-in-final-association-score/1421/2 "2024-05-08T11:06:25Z")

</div>

Hi @gatla, and welcome to the Open Targets Community! 🎉

The L2G scores for genes are the evidence scores for the OT Genetics datasource. We apply a harmonic sum to the evidence scores, divided by the theoretical maximum, to calculate the data source score.

  

As a simple example, let’s take a look at the OT Genetics evidence for PCSK9 in familial hypercholesterolemia:

 ![Screenshot 2024-05-08 at 12.00.28](https://europe1.discourse-cdn.com/flex017/uploads/opentargets/original/1X/2276e13c8b4271ea275148b81b47557999cd6848.png)

  

- There is one L2G score: 0.76377
- If we divide this by the theoretical maximum, we have: 0.76377/1.644 = 0.46458…
- This is the OT Genetics score that you can see by hovering over the cell (0.46)

  
  
  

You can find more information about the scoring calculations in our documentation.

> **[Target - disease associations | Open Targets Platform Documentation](https://platform-docs.opentargets.org/associations#by-data-source)**

  

Let me know if you have further questions!