# Conserved regions variants

**URL:** https://community.opentargets.org/t/conserved-regions-variants/707
**Category:** Open Targets Genetics FAQs
**Tags:** genetics-portal
**Created:** [21 July 2022 08:21 UTC](https://community.opentargets.org/t/conserved-regions-variants/707 "2022-07-21T08:21:39Z")
**Posts on this page:** 3
**Page:** 1

<div class="post-metadata">

### Author: ![Sophia\_2M](https://avatars.discourse-cdn.com/v4/letter/s/c6cbf5/32.png) [@Sophia\_2M](https://community.opentargets.org/u/Sophia_2M)
#### Post date: [21 July 2022 08:21 UTC](https://community.opentargets.org/t/conserved-regions-variants/707/1 "2022-07-21T08:21:40Z")

</div>

Hello! Apologies if this has an obvious answer; I am new here! Is there a way to find which of the variants in the database are in conserved regions? Basically, apart from the annotation of coding or intron variant, is there one for conserved, too?  
Thank, in advance!

---

<div class="post-metadata">

### Author: ![Xiangyu](https://avatars.discourse-cdn.com/v4/letter/x/90db22/32.png) [@Xiangyu](https://community.opentargets.org/u/Xiangyu)
#### Post date: [27 July 2022 12:55 UTC](https://community.opentargets.org/t/conserved-regions-variants/707/2 "2022-07-27T12:55:49Z")

</div>

Hi Sophia,

We take into account the conservation of each SNP in the form of CADD score, which is derived partly from the conservation of each SNP. However, the raw conservation information is not available from Open Target Genetics.

Best wishes,  
Xiangyu

---

<div class="post-metadata">

### Author: ![Sophia\_2M](https://avatars.discourse-cdn.com/v4/letter/s/c6cbf5/32.png) [@Sophia\_2M](https://community.opentargets.org/u/Sophia_2M)
#### Post date: [27 July 2022 13:14 UTC](https://community.opentargets.org/t/conserved-regions-variants/707/3 "2022-07-27T13:14:19Z")

</div>

Dear Xiangyu,

Thank you for taking the time to reply.

Best wishes,  
Sophia