# Burden, SKAT and SKAT-O test of Genebass in ot-platform

**URL:** <https://community.opentargets.org/t/burden-skat-and-skat-o-test-of-genebass-in-ot-platform/1302>\
**Category:** General\
**Tags:** ot-platform\
**Created:** [4 December 2023 21:15 UTC](https://community.opentargets.org/t/burden-skat-and-skat-o-test-of-genebass-in-ot-platform/1302 "2023-12-04T21:15:57Z")\
**Posts on this page:** 3\
**Page:** 1

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**Author:** ![Shicheng\_Guo](https://dub1.discourse-cdn.com/flex017/user_avatar/community.opentargets.org/shicheng_guo/32/217_2.png) [@Shicheng\_Guo](https://community.opentargets.org/u/Shicheng_Guo)\
**Post date:** [4 December 2023 21:15 UTC](https://community.opentargets.org/t/burden-skat-and-skat-o-test-of-genebass-in-ot-platform/1302/1 "2023-12-04T21:15:57Z")

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Dear Team,

I am wondering are we also able to show SKAT and SKAT-O test of Genebass result in ot-platform, currently, looks we only included Burden test result, correct?

Thanks.

Shicheng

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**Author:** ![irene](https://dub1.discourse-cdn.com/flex017/user_avatar/community.opentargets.org/irene/32/50_2.png) [@irene](https://community.opentargets.org/u/irene)\
**Post date:** [5 December 2023 11:21 UTC](https://community.opentargets.org/t/burden-skat-and-skat-o-test-of-genebass-in-ot-platform/1302/2 "2023-12-05T11:21:58Z")

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Dear @Shicheng_Guo,

you are correct in that we haven’t integrated SKAT and SKAT-O test results from Genebass. Our primary focus has been on reporting burden test results, which aggregate the effect of variants within a gene into a single statistical, unlike SKAT and SKAT-O models. This is a very good fit to us, as it allows us to establish and to measure gene/trait associations.

However, we do include results from SKAT or SKAT-O tests for relevant publications where no burden results are available. For example, results on Parkinson disease by the AMP-PD initiative.

I hope that clarifies your question. Please let me know if you see value in expanding our approach.

Best,  
Irene

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<div class="post-metadata">

**Author:** ![Shicheng\_Guo](https://dub1.discourse-cdn.com/flex017/user_avatar/community.opentargets.org/shicheng_guo/32/217_2.png) [@Shicheng\_Guo](https://community.opentargets.org/u/Shicheng_Guo)\
**Post date:** [6 December 2023 07:20 UTC](https://community.opentargets.org/t/burden-skat-and-skat-o-test-of-genebass-in-ot-platform/1302/3 "2023-12-06T07:20:30Z")

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Agree with you, burden test is the best model for interpretation. I think Genebass loss lots of burden test result (I don’t know the reason, but I do believe some result should be significant in burden test model, but they are not existed in Genebass system). Anyway, I think only keep burden test is a great choice!!

Thanks Irene!!