# APOL1 variants with established role in kidney diseases

**URL:** <https://community.opentargets.org/t/apol1-variants-with-established-role-in-kidney-diseases/1410>\
**Category:** General\
**Tags:** kidney\
**Created:** [23 April 2024 15:13 UTC](https://community.opentargets.org/t/apol1-variants-with-established-role-in-kidney-diseases/1410 "2024-04-23T15:13:39Z")\
**Posts on this page:** 1\
**Page:** 1

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**Author:** ![QiheXu](https://avatars.discourse-cdn.com/v4/letter/q/7ab992/32.png) [@QiheXu](https://community.opentargets.org/u/QiheXu)\
**Post date:** [23 April 2024 15:13 UTC](https://community.opentargets.org/t/apol1-variants-with-established-role-in-kidney-diseases/1410/1 "2024-04-23T15:13:39Z")

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OpenTarget Genetics is my go-for database for genetic variants. When searching APOL1 missense variants rs73885319, rs60910145 and rs71785313, I only found the first two in the database. When I searched the genetic variants using the gene name APOL1, only the first was among the associated genetic variants datasheet. Biallelic expression of the G1 ( **rs73885319** or rs60910145) and/or G2 (rs71785313) variants of APOL1 have well-established role in kidney diseases. It would be great to see all these three variants, as well as a newer protective variant known as p.N264K ([https://www.ajkd.org/article/S0272-6386(24)00742-X/abstract](https://www.ajkd.org/article/S0272-6386(24)00742-X/abstract)) can be included in the database. Many thanks!