# 25.12 Release now live! **URL:** \ **Category:** Releases\ **Created:** [10 December 2025 14:54 UTC](https://community.opentargets.org/t/25-12-release-now-live/1951 "2025-12-10T14:54:57Z")\ **Posts on this page:** 11\ **Page:** 1
**Author:** ![hcornu](https://dub1.discourse-cdn.com/flex017/user_avatar/community.opentargets.org/hcornu/32/716_2.png) [@hcornu](https://community.opentargets.org/u/hcornu)\ **Post date:** [10 December 2025 14:54 UTC](https://community.opentargets.org/t/25-12-release-now-live/1951/1 "2025-12-10T14:54:57Z")
We have just released the latest update to the Open Targets Platform — 25.12 ## Key stats | Metric | Count | | --- | --- | | Targets | 78,725 | | Diseases/phenotypes | 46,960 | | Drugs/clinical candidates | 18,475 | | Evidence | 32,515,132 | | Associations | 12,010,760 | ## Number of credible sets | Study type | Count | | --- | --- | | tuqtl | 384,849 | | gwas | 1,440,589 | | sqtl | 223,500 | | pqtl | 33,731 | | eqtl | 1,349,418 | | sceqtl | 52,738 | Number of unique studies with at least one credible set: 51,805 (GWAS) Number of unique biosampleIDs (number of tissues/cell-types) from molQTLs: 98 ## Evidence metrics for this release: - 3,535,067 genetic evidence from [European Variation Archive (EVA)](http://www.ebi.ac.uk/eva/) - 2,976,160 GWAS credible sets from [GWAS Catalog](https://www.ebi.ac.uk/gwas/), [FinnGen](https://www.finngen.fi/en) through Gentropy - 5,062 genetic evidence from [Gene2Phenotype](https://www.ebi.ac.uk/gene2phenotype) - 48,545 genetic evidence from the [Genomics England PanelApp](https://bioinfo.extge.co.uk/crowdsourcing/PanelApp/) - 3,904 genetic evidence from [ClinGen](https://search.clinicalgenome.org/kb/gene-validity/) - 7,189genetic evidence from [Orphanet](https://www.orpha.net/) - 41,264 genetic evidence from Gene burden - 21,681 genetic evidence from [CRISPRBrain](https://crisprbrain.org/) - 6,735 genetic evidence from [UniProt Literature](https://www.uniprot.org/) - 9,342 somatic evidence from [European Variation Archive (EVA)](http://www.ebi.ac.uk/eva/) - 4,223 somatic evidence from [intOGen](https://www.intogen.org/) - 91,572 somatic evidence from the [Cancer Gene Census](http://cancer.sanger.ac.uk/census/) - 36,870 somatic evidence from [Uniprot](http://www.uniprot.org/) - 569,506 drug evidence from [ChEMBL](https://www.ebi.ac.uk/chembl/) - 237,329 expression evidence from [Expression Atlas](https://www.ebi.ac.uk/gxa/home) - 10,211 affected pathway evidence from [Reactome](https://reactome.org/) - 1,301 somatic evidence from the [Cancer Genome Interpreter](https://www.cancergenomeinterpreter.org/home) - 517 CRISPR-Cas9 (Cancer Cell Lines) evidence from Pacini et al. (2024) - 1,563,525 mouse model evidence from [IMPC](https://www.mousephenotype.org/) - 23,345,129 scientific literature evidence from co-occurrence mining in [Europe PMC](https://europepmc.org/) For more details and numbers, read the [25.12 blog post](https://blog.opentargets.org/open-targets-platform-25-12-has-been-released/). ---
**Author:** ![pgodard](https://dub1.discourse-cdn.com/flex017/user_avatar/community.opentargets.org/pgodard/32/487_2.png) [@pgodard](https://community.opentargets.org/u/pgodard)\ **Post date:** [13 December 2025 07:16 UTC](https://community.opentargets.org/t/25-12-release-now-live/1951/2 "2025-12-13T07:16:59Z")
Hi, Thank you for this new release and making all these data available. After downloading and checking the data, I think that protein expression (at least per cell type) is missing. It seems to be also the case for mouse model literature references. These information have NA values for a few targets I checked on the web site ( [Open Targets Platform](https://platform.opentargets.org/target/ENSG00000198793) , [Open Targets Platform](https://platform.opentargets.org/target/ENSG00000141510) ) Is it normal/expected? ---
**Author:** ![hcornu](https://dub1.discourse-cdn.com/flex017/user_avatar/community.opentargets.org/hcornu/32/716_2.png) [@hcornu](https://community.opentargets.org/u/hcornu)\ **Post date:** [16 December 2025 09:30 UTC](https://community.opentargets.org/t/25-12-release-now-live/1951/3 "2025-12-16T09:30:28Z")
Hi @pgodard and welcome to the Open Targets Community! Thank you for reporting this. We’ve seen your message and we’re looking into it! ---
**Author:** ![dsuveges](https://dub1.discourse-cdn.com/flex017/user_avatar/community.opentargets.org/dsuveges/32/30_2.png) [@dsuveges](https://community.opentargets.org/u/dsuveges)\ **Post date:** [6 January 2026 10:48 UTC](https://community.opentargets.org/t/25-12-release-now-live/1951/4 "2026-01-06T10:48:51Z")
Hi @pgodard , Thanks again for reporting this bug! We have addressed the [issue](https://github.com/opentargets/issues/issues/4177) at code level and also applied a patch on the released data. Now, all our distributions contains the right dataset: UI, BigQuery, API and FTP. We have made mayor updates in our data processing pipelines/processes with the last release, so please keep us posted in case you encounter anything suspicious. Thank you. Best, Daniel ---
**Author:** ![pgodard](https://dub1.discourse-cdn.com/flex017/user_avatar/community.opentargets.org/pgodard/32/487_2.png) [@pgodard](https://community.opentargets.org/u/pgodard)\ **Post date:** [6 January 2026 11:26 UTC](https://community.opentargets.org/t/25-12-release-now-live/1951/5 "2026-01-06T11:26:15Z")
Thank you for correcting the issue with protein expression. However, it seems that references to the literature for mouse models are still missing, as shown below: ![image](https://europe1.discourse-cdn.com/flex017/uploads/opentargets/original/1X/25413d7feec2bba037669da906419f176d719616.png) Do you plan to correct this? I didn’t notice a corresponding GitHub issue for it. Thanks again for your support. ---
**Author:** ![dsuveges](https://dub1.discourse-cdn.com/flex017/user_avatar/community.opentargets.org/dsuveges/32/30_2.png) [@dsuveges](https://community.opentargets.org/u/dsuveges)\ **Post date:** [12 January 2026 14:18 UTC](https://community.opentargets.org/t/25-12-release-now-live/1951/6 "2026-01-12T14:18:03Z")
Hi @pgodard, The lack of literature references on the Mouse Phenotype widget has been addressed under [#4169](https://github.com/opentargets/issues/issues/4169), however the fix in the data is not rolled out due to a number of complicated consequences. The fix will be out with the next release, which is due around the second half of March. Sorry for the inconveniences caused. Best, Daniel ---
**Author:** ![pgodard](https://dub1.discourse-cdn.com/flex017/user_avatar/community.opentargets.org/pgodard/32/487_2.png) [@pgodard](https://community.opentargets.org/u/pgodard)\ **Post date:** [13 January 2026 05:10 UTC](https://community.opentargets.org/t/25-12-release-now-live/1951/7 "2026-01-13T05:10:28Z")
Hi @dsuveges , Thanks for the follow-up and for having fixed the issue. Kind regards Patrice ---
**Author:** ![jhju](https://dub1.discourse-cdn.com/flex017/user_avatar/community.opentargets.org/jhju/32/593_2.png) [@jhju](https://community.opentargets.org/u/jhju)\ **Post date:** [23 January 2026 17:58 UTC](https://community.opentargets.org/t/25-12-release-now-live/1951/8 "2026-01-23T17:58:05Z")
Dear @dsuveges , @hcornu , Thanks for continuing to improve and develop open targets. It has been a great resource for research. I was checking the tables on BigQuery and noticed that the evidence table only has a little over 1000 rows way fewer than what is shown in the release notes (32,515,132). Could someone verify that the table was uploaded correctly? Thank you! ![Screenshot 2026-01-23 at 9.55.27 AM](https://europe1.discourse-cdn.com/flex017/uploads/opentargets/original/1X/28010776bee7fb6c6c7315446a6f0767f5810e49.png) ---
**Author:** ![dsuveges](https://dub1.discourse-cdn.com/flex017/user_avatar/community.opentargets.org/dsuveges/32/30_2.png) [@dsuveges](https://community.opentargets.org/u/dsuveges)\ **Post date:** [26 January 2026 09:45 UTC](https://community.opentargets.org/t/25-12-release-now-live/1951/9 "2026-01-26T09:45:26Z")
Hello! And welcome to the Open Targets community! Yes, this is bug. It has been reported under [this](https://community.opentargets.org/t/need-help-with-my-google-bigquery-it-appears-that-europepmc-evidence-now-returns-zero-records/1960) community post. Although it has been resolved on our end immediately, Google only syncs data every first day of the month. So we need to wait for another week to see the effect. We keep our eyes on the updated data and will let you know if there’s any outstanding concern. In the meantime, please don’t hesitate reaching out if you see anything strange. Best, Daniel ---
**Author:** ![dsuveges](https://dub1.discourse-cdn.com/flex017/user_avatar/community.opentargets.org/dsuveges/32/30_2.png) [@dsuveges](https://community.opentargets.org/u/dsuveges)\ **Post date:** [2 February 2026 08:12 UTC](https://community.opentargets.org/t/25-12-release-now-live/1951/10 "2026-02-02T08:12:33Z")
Hi, I can confirm, the Platform dataset has been updated on BigQuery! This query: ```sql SELECT evidence.datasourceId, COUNT(*) as record_count FROM `bigquery-public-data.open_targets_platform.evidence_*` AS evidence WHERE evidence.targetId = "ENSG00000139618" GROUP BY evidence.datasourceId ORDER BY record_count DESC; ``` Give this output: ```auto 1 eva 71084 2 europepmc 21709 3 gene_burden 609 4 gwas_credible_sets 463 5 cancer_gene_census 246 6 eva_somatic 118 7 genomics_england 106 8 uniprot_variants 96 9 impc 67 10 intogen 19 11 cancer_biomarkers 12 12 expression_atlas 11 13 reactome 8 14 uniprot_literature 7 15 orphanet 5 16 gene2phenotype 3 17 clingen 2 18 crispr 1 19 crispr_screen 1 ``` The different evidence sources are stored in distinct tables named as `evidence_{sourceId}`, so if you want to read all evidence you’ll need to read all tables as `FROM `bigquery-public-data.open_targets_platform.evidence_*` AS evidence`. And from now on, you don’t need to apply a filter if you want to work with source specific evidence. **One caveat** : for some reason, Google syncs data without dropping tables that are no longer found in our datasets, so the `evidence` table is still there, please don’t use it, or read all evidence as `evidence*`. We’ll reach out to Google to make sure this table will not be propagated for the next release. ![image](https://europe1.discourse-cdn.com/flex017/uploads/opentargets/original/1X/a5c6c05898b81c11b54e4910fce9d6e7534c5605.png) Please keep us informed if you still found anything strange. Best, Daniel ---
**Author:** ![jhju](https://dub1.discourse-cdn.com/flex017/user_avatar/community.opentargets.org/jhju/32/593_2.png) [@jhju](https://community.opentargets.org/u/jhju)\ **Post date:** [5 February 2026 20:10 UTC](https://community.opentargets.org/t/25-12-release-now-live/1951/11 "2026-02-05T20:10:19Z")
Thank you very much for the follow up, @dsuveges ! Really appreciate it!