# Technical Support **URL:** https://community.opentargets.org/c/technical-support/10.md [Latest](https://community.opentargets.org/latest.md) · [Categories](https://community.opentargets.org/categories.md) · [Tags](https://community.opentargets.org/tags.md) --- ## [About the Technical Support category](https://community.opentargets.org/t/about-the-technical-support-category/33)
**Author:** [@community\_manager](https://community.opentargets.org/u/community_manager)\ **Replies:** 0
Questions about the infrastructure and codebase of the Open Targets Platform and Open Targets Genetics. Note, some information is already available in the ‘Technical Pipeline’ section of the Open Targets Genetics docume… --- ## [Input for SuSIE-Inf from gentropy](https://community.opentargets.org/t/input-for-susie-inf-from-gentropy/1864)
**Author:** [@abhukku](https://community.opentargets.org/u/abhukku)\ **Replies:** 4\ **Last updated:** [3 September 2026 09:29 UTC](https://community.opentargets.org/t/input-for-susie-inf-from-gentropy/1864 "2026-09-03T09:29:09Z")
Hi! I was looking through the gentropy code, and I noticed, from the locus\_breaker\_clumping.py script, that there was p-value filtering done (line 68). Seeing as these results seem to feed directly into the susie-inf pip… --- ## [Were the openfda\_adverse\_target\_reactions and ChEMBL evidence datasets discontinued in 26.06?](https://community.opentargets.org/t/were-the-openfda-adverse-target-reactions-and-chembl-evidence-datasets-discontinued-in-26-06/2058)
**Author:** [@spletsx](https://community.opentargets.org/u/spletsx)\ **Replies:** 2\ **Last updated:** [4 August 2026 01:46 UTC](https://community.opentargets.org/t/were-the-openfda-adverse-target-reactions-and-chembl-evidence-datasets-discontinued-in-26-06/2058 "2026-08-04T01:46:08Z")
Hello Open Targets team, We are updating our data pipeline from Open Targets Platform release 25.09 to release 26.06. We could not find the following datasets in the 26.06 downloads: openfda\_adverse\_target\_reactions e… --- ## [Binned value of expression - difficulty replicating distribution](https://community.opentargets.org/t/binned-value-of-expression-difficulty-replicating-distribution/1773)
**Author:** [@graceLBI](https://community.opentargets.org/u/graceLBI)\ **Replies:** 15\ **Last updated:** [3 August 2026 09:37 UTC](https://community.opentargets.org/t/binned-value-of-expression-difficulty-replicating-distribution/1773 "2026-08-03T09:37:26Z")
If you download the binned gene expression data from open targets, values are distributed across the bins with the majority of values in bin 1-4 and then some in 5 and a small number in the higher bins. If I try and rep… --- ## [I'm trying to look up different SNPs like I used to do 2 years ago](https://community.opentargets.org/t/im-trying-to-look-up-different-snps-like-i-used-to-do-2-years-ago/2023)
**Author:** [@val5678](https://community.opentargets.org/u/val5678)\ **Replies:** 2\ **Last updated:** [24 May 2026 00:22 UTC](https://community.opentargets.org/t/im-trying-to-look-up-different-snps-like-i-used-to-do-2-years-ago/2023 "2026-05-24T00:22:44Z")
I’m trying to look up different SNPs like I used to do 2 years ago, where on the main page of any SNP, you see a graph of all the cancer associations with betas or OR’s listed, or all the autoimmune associations, etc. Ho… --- ## [Release 25.12 GraphQLQuery API does not match with Opentargets Platform results for Breast Cancer](https://community.opentargets.org/t/release-25-12-graphqlquery-api-does-not-match-with-opentargets-platform-results-for-breast-cancer/1982)
**Author:** [@koryclick](https://community.opentargets.org/u/koryclick)\ **Replies:** 3\ **Last updated:** [23 March 2026 16:52 UTC](https://community.opentargets.org/t/release-25-12-graphqlquery-api-does-not-match-with-opentargets-platform-results-for-breast-cancer/1982 "2026-03-23T16:52:48Z")
Hello, I was doing this GraphQL query : Variables: {“diseaseId”: “MONDO\_0007254”} query BreastCancerTargets($diseaseId: String!) { disease(efoId: $diseaseId) { id name associatedTargets(page: { size: 10… --- ## [Differences in "L2G share" as computed from v8 (Oct 2022) and v25.12?](https://community.opentargets.org/t/differences-in-l2g-share-as-computed-from-v8-oct-2022-and-v25-12/1983)
**Author:** [@shastvx1](https://community.opentargets.org/u/shastvx1)\ **Replies:** 2\ **Last updated:** [19 March 2026 19:29 UTC](https://community.opentargets.org/t/differences-in-l2g-share-as-computed-from-v8-oct-2022-and-v25-12/1983 "2026-03-19T19:29:51Z")
Hello, We’re interested in computing “L2G share” scores as defined in Minikel et al 2024 using L2G values in the v25.12 release of Open Targets. As per their publication, they used v8 (Oct 2022), with the final share sc… --- ## [Multiple questions about GraphQL schemata](https://community.opentargets.org/t/multiple-questions-about-graphql-schemata/1919)
**Author:** [@jpfeuffer](https://community.opentargets.org/u/jpfeuffer)\ **Replies:** 3\ **Last updated:** [12 September 2025 14:18 UTC](https://community.opentargets.org/t/multiple-questions-about-graphql-schemata/1919 "2025-09-12T14:18:34Z")
Hi! I am struggling a lot with the lack of documentation of the GraphQL endpoint. "associations on the fly" associatedTargets( "List of disease or target IDs" Bs: \\\[String!\\\], "Use the disease ontology… --- ## [GraphQL query for expression data](https://community.opentargets.org/t/graphql-query-for-expression-data/1840)
**Author:** [@mturchin20](https://community.opentargets.org/u/mturchin20)\ **Replies:** 9\ **Last updated:** [30 June 2025 02:55 UTC](https://community.opentargets.org/t/graphql-query-for-expression-data/1840 "2025-06-30T02:55:29Z")
Hello, I am trying to run a GraphQL query to pull expression data for a target. Based on the schema (https://api.platform.opentargets.org/api/v4/graphql/schema), it looks like I should use the term ‘expressions’. Howeve… --- ## [Harmonization by effect allele using gentropy](https://community.opentargets.org/t/harmonization-by-effect-allele-using-gentropy/1753)
**Author:** [@abhukku](https://community.opentargets.org/u/abhukku)\ **Replies:** 1\ **Last updated:** [14 April 2025 08:59 UTC](https://community.opentargets.org/t/harmonization-by-effect-allele-using-gentropy/1753 "2025-04-14T08:59:24Z")
Hello! I had a question about the harmonization script within gentropy. Is the harmonization by effect allele (i.e. flipping effect allele/effect size of the variant when necessary) inherent to this script, or is it ass… --- ## [Gold standard for new L2G scores](https://community.opentargets.org/t/gold-standard-for-new-l2g-scores/1740)
**Author:** [@abhukku](https://community.opentargets.org/u/abhukku)\ **Replies:** 3\ **Last updated:** [2 April 2025 15:52 UTC](https://community.opentargets.org/t/gold-standard-for-new-l2g-scores/1740 "2025-04-02T15:52:07Z")
Hi all, Thank you for the recent update to the platform including the new L2G scores! I’ve been looking through them and was just wondering, was the gold standard used for the model training the same as in the previous … --- ## [Target Level Tractability Doesn't Match "Known Drugs"](https://community.opentargets.org/t/target-level-tractability-doesnt-match-known-drugs/1599)
**Author:** [@spadavecchio](https://community.opentargets.org/u/spadavecchio)\ **Replies:** 1\ **Last updated:** [4 November 2024 10:25 UTC](https://community.opentargets.org/t/target-level-tractability-doesnt-match-known-drugs/1599 "2024-11-04T10:25:42Z")
If you review a specific target, say BTK, you will see that the Tractability section reports that it doesn’t have anything in any clinical phases for SM: However, if you look at the “known drugs” section, its clear th… --- ## [Open Targets Genetics local setup](https://community.opentargets.org/t/open-targets-genetics-local-setup/1585)
**Author:** [@shailesh](https://community.opentargets.org/u/shailesh)\ **Replies:** 1\ **Last updated:** [14 October 2024 10:04 UTC](https://community.opentargets.org/t/open-targets-genetics-local-setup/1585 "2024-10-14T10:04:25Z")
I am able to run the Open Target platform at my local machine using standalone-deployment-platform. There is Open Target Genetics platform, is there any repository to run this platform on my local machine like standalon… --- ## [How to deploy a local instance of OpenTargets?](https://community.opentargets.org/t/how-to-deploy-a-local-instance-of-opentargets/288)
**Author:** [@njeanray](https://community.opentargets.org/u/njeanray)\ **Replies:** 3\ **Last updated:** [27 September 2024 12:29 UTC](https://community.opentargets.org/t/how-to-deploy-a-local-instance-of-opentargets/288 "2024-09-27T12:29:57Z")
Hi OpenTargets Community, I’d like to deploy my own local instance of OpenTargets in order to perform some specific developments and to add new data sources specific to our activities. I already read a lot of informatio… --- ## [Bulk PheWAS data download](https://community.opentargets.org/t/bulk-phewas-data-download/1488)
**Author:** [@jisu](https://community.opentargets.org/u/jisu)\ **Replies:** 3\ **Last updated:** [26 July 2024 08:21 UTC](https://community.opentargets.org/t/bulk-phewas-data-download/1488 "2024-07-26T08:21:24Z")
Hello, I’m a beginner for accessing and utilizing GWAS / PheWAS data. I’d like to operate meta-analysis of PheWAS & GWAS data from various biobanks in order to achieve more significant PheWAS & GWAS data. Could I get … --- ## [Are OpenTargets in collaboration with All of Us?](https://community.opentargets.org/t/are-opentargets-in-collaboration-with-all-of-us/1359)
**Author:** [@QiheXu](https://community.opentargets.org/u/QiheXu)\ **Replies:** 2\ **Last updated:** [26 February 2024 13:25 UTC](https://community.opentargets.org/t/are-opentargets-in-collaboration-with-all-of-us/1359 "2024-02-26T13:25:45Z")
Dear OpenTargets colleagues, All of Us finds many millions of new DNA variants as it moves toward 1 million participants from diverse backgrounds: https://www.science.org/content/article/quarter-million-genomes-analyzed… --- ## [Blocked during the download of files](https://community.opentargets.org/t/blocked-during-the-download-of-files/1197)
**Author:** [@hoti](https://community.opentargets.org/u/hoti)\ **Replies:** 5\ **Last updated:** [6 February 2024 11:41 UTC](https://community.opentargets.org/t/blocked-during-the-download-of-files/1197 "2024-02-06T11:41:57Z")
Hi, We try to download all the following files present in the site http://ftp.ebi.ac.uk using Python : /pub/databases/opentargets/genetics/latest/d2v2g/ /pub/databases/opentargets/genetics/latest/l2g/ /pub/databases/o… --- ## [Html markup included in text mining results](https://community.opentargets.org/t/html-markup-included-in-text-mining-results/1307)
**Author:** [@adinarzo](https://community.opentargets.org/u/adinarzo)\ **Replies:** 1\ **Last updated:** [7 December 2023 15:59 UTC](https://community.opentargets.org/t/html-markup-included-in-text-mining-results/1307 "2023-12-07T15:59:49Z")
A picture is sometimes worth a thousand words: Note the ‘\’ html tag spelled out within the paragraph. Among other things, this makes it appear as if the target and disease were in the same sentence, when in fact … --- ## [Missing paper from text mining](https://community.opentargets.org/t/missing-paper-from-text-mining/1306)
**Author:** [@adinarzo](https://community.opentargets.org/u/adinarzo)\ **Replies:** 1\ **Last updated:** [7 December 2023 14:36 UTC](https://community.opentargets.org/t/missing-paper-from-text-mining/1306 "2023-12-07T14:36:18Z")
Dear Open Targets team, I found an issue with the literature text mining resource. Specifically, my question is why a specific paper was not found by Europe PMC text mining, where it seems to me it should have matched a… --- ## [CGNL1 Variants are retrieved when searching for ALDH1A2 variants](https://community.opentargets.org/t/cgnl1-variants-are-retrieved-when-searching-for-aldh1a2-variants/1205)
**Author:** [@QiheXu](https://community.opentargets.org/u/QiheXu)\ **Replies:** 2\ **Last updated:** [21 September 2023 10:31 UTC](https://community.opentargets.org/t/cgnl1-variants-are-retrieved-when-searching-for-aldh1a2-variants/1205 "2023-09-21T10:31:26Z")
SirTarget. Dear Open Targets Team, I searched the keyword ALDH1A2 and arrived at this web link for the ALDH1A2 gene: Open Targets Genetics. I downloaded the CSV file on ALDH1A2 variants correlated with different pheno… --- ## [Why are there some inconsistencies in evidence count?](https://community.opentargets.org/t/why-are-there-some-inconsistencies-in-evidence-count/1191)
**Author:** [@charlie](https://community.opentargets.org/u/charlie)\ **Replies:** 3\ **Last updated:** [7 September 2023 10:54 UTC](https://community.opentargets.org/t/why-are-there-some-inconsistencies-in-evidence-count/1191 "2023-09-07T10:54:37Z")
Hello Open Targets, My main goal is to find all evidence that is used to calculate the association score. For this purpose, I encountered two related problems listed as follows. Inconsistency between Webpage and BigQu… --- ## [Tag Release not updated](https://community.opentargets.org/t/tag-release-not-updated/1159)
**Author:** [@cinzia](https://community.opentargets.org/u/cinzia)\ **Replies:** 2\ **Last updated:** [26 July 2023 17:04 UTC](https://community.opentargets.org/t/tag-release-not-updated/1159 "2023-07-26T17:04:11Z")
Dear all, greetings from a former colleague. Is there any specific reason why the tags releases were not updated anymore? Specifically I see there is a jar ETL file and the relative conf but without tag information … --- ## [Gecko function in graphql not working](https://community.opentargets.org/t/gecko-function-in-graphql-not-working/1103)
**Author:** [@Zhana\_Kuncheva](https://community.opentargets.org/u/Zhana_Kuncheva)\ **Replies:** 3\ **Last updated:** [13 July 2023 02:04 UTC](https://community.opentargets.org/t/gecko-function-in-graphql-not-working/1103 "2023-07-13T02:04:05Z")
Hi all, We have been quering the gecko function for indexVariants (and tagVariants) in a region of interest but it has not been outputting anything although we know there is information there. Example { gecko(chromos… --- ## [Create an OpenTargets fullstack clone](https://community.opentargets.org/t/create-an-opentargets-fullstack-clone/950)
**Author:** [@Ben\_Hitz](https://community.opentargets.org/u/Ben_Hitz)\ **Replies:** 8\ **Last updated:** [20 March 2023 10:57 UTC](https://community.opentargets.org/t/create-an-opentargets-fullstack-clone/950 "2023-03-20T10:57:04Z")
Hi, I run the DACC for the Impact of Genomic Function on Variation consortium . It has been suggested that the IGVF extend OpenTargets software rather than build our own giant genomics db from scratch. In order to do t… --- ## [PheWAS figure cutoff - need to use GraphQL?](https://community.opentargets.org/t/phewas-figure-cutoff-need-to-use-graphql/1112)
**Author:** [@jstrosahl](https://community.opentargets.org/u/jstrosahl)\ **Replies:** 3\ **Last updated:** [18 June 2023 21:43 UTC](https://community.opentargets.org/t/phewas-figure-cutoff-need-to-use-graphql/1112 "2023-06-18T21:43:21Z")
I’m working on a manuscript for publication, and we intend to include a PheWAS plot for a SNP in the paper (found at this link). However, the names of several traits are cut-off at the bottom of the figure. Is there a wa… --- ## [Getting "cannot resolve '\`statisticalTestTail\`'" error when processing evidence files for release 23.02](https://community.opentargets.org/t/getting-cannot-resolve-statisticaltesttail-error-when-processing-evidence-files-for-release-23-02/972)
**Author:** [@thondeboer](https://community.opentargets.org/u/thondeboer)\ **Replies:** 2\ **Last updated:** [10 May 2023 10:38 UTC](https://community.opentargets.org/t/getting-cannot-resolve-statisticaltesttail-error-when-processing-evidence-files-for-release-23-02/972 "2023-05-10T10:38:03Z")
When trying to process the “evidence” files with the opentargets-etl-backend program, I run into an error I cannot figure out what to do with. Exception in thread "main" org.apache.spark.sql.AnalysisException: cannot re… --- ## [Documentation Clarity - Platform ETL](https://community.opentargets.org/t/documentation-clarity-platform-etl/912)
**Author:** [@Cole\_DeVries](https://community.opentargets.org/u/Cole_DeVries)\ **Replies:** 1\ **Last updated:** [7 January 2023 11:53 UTC](https://community.opentargets.org/t/documentation-clarity-platform-etl/912 "2023-01-07T11:53:45Z")
I am trying to use AWS Elastic Map Reduce (EMR) Serverless to replicate the steps that are taken in the following repository: GitHub - opentargets/platform-etl-backend. I want to overwrite the reference.conf configurati… --- ## [Variant GraphQL query not working](https://community.opentargets.org/t/variant-graphql-query-not-working/898)
**Author:** [@aidanmacn](https://community.opentargets.org/u/aidanmacn)\ **Replies:** 1\ **Last updated:** [19 December 2022 15:24 UTC](https://community.opentargets.org/t/variant-graphql-query-not-working/898 "2022-12-19T15:24:29Z")
Hi, there seems to be an issue with GraphQL queries at the variant level: Thanks, Aidan --- ## [Can I create my own graphql database for use in the Platform UI from the data download?](https://community.opentargets.org/t/can-i-create-my-own-graphql-database-for-use-in-the-platform-ui-from-the-data-download/829)
**Author:** [@thondeboer](https://community.opentargets.org/u/thondeboer)\ **Replies:** 2\ **Last updated:** [9 November 2022 17:04 UTC](https://community.opentargets.org/t/can-i-create-my-own-graphql-database-for-use-in-the-platform-ui-from-the-data-download/829 "2022-11-09T17:04:47Z")
Is there some docs or code to help me create my own GraphQL database from the data download? We would like to extend the information in the database and create our own version of the Platform for internal use, showing th… --- ## [Search from expression profile](https://community.opentargets.org/t/search-from-expression-profile/810)
**Author:** [@Green](https://community.opentargets.org/u/Green)\ **Replies:** 2\ **Last updated:** [21 October 2022 04:40 UTC](https://community.opentargets.org/t/search-from-expression-profile/810 "2022-10-21T04:40:58Z")
I am looking for proteins or markers specifically expressed in a certain kind of epithelial cells. As your query box for search is for protein names or disease names, can I search from baseline expression profile? How? … [Next page](https://community.opentargets.org/c/technical-support/10.md?page=1)