# Data issue **URL:** https://community.opentargets.org/c/community-feedback/data-issue/35.md [Latest](https://community.opentargets.org/latest.md) · [Categories](https://community.opentargets.org/categories.md) · [Tags](https://community.opentargets.org/tags.md) --- ## [About the Data issue category](https://community.opentargets.org/t/about-the-data-issue-category/58)
**Author:** [@community\_manager](https://community.opentargets.org/u/community_manager)\ **Replies:** 0
Discuss any problems you come across when using Open Targets data. Please make sure to clarify whether you are referring to Open Targets Platform data or Open Targets Genetics data, to make it easier for people to help … --- ## [Questions regarding the accuracy of data in the Drugs and Clinical Candidates section](https://community.opentargets.org/t/questions-regarding-the-accuracy-of-data-in-the-drugs-and-clinical-candidates-section/2024)
**Author:** [@chen\_lv](https://community.opentargets.org/u/chen_lv)\ **Replies:** 4\ **Last updated:** [19 May 2026 01:37 UTC](https://community.opentargets.org/t/questions-regarding-the-accuracy-of-data-in-the-drugs-and-clinical-candidates-section/2024 "2026-05-19T01:37:52Z")
First of all, I am very grateful for the Open Targets tool, which has brought a lot of convenience to research. When I was searching for drugs related to UC, I found a problem: Aspirin (acetylsalicylic acid) is a classic… --- ## [Lack of approved drug indications](https://community.opentargets.org/t/lack-of-approved-drug-indications/327)
**Author:** [@sigven](https://community.opentargets.org/u/sigven)\ **Replies:** 8\ **Last updated:** [22 September 2025 13:34 UTC](https://community.opentargets.org/t/lack-of-approved-drug-indications/327 "2025-09-22T13:34:19Z")
Hi, I cannot seem to make sense of the indications that are approved for particular drugs (cancer drugs in particular). It seems you now define “approved indication” when an indication is listed for the drug in a clinic… --- ## [Variant table and VEP annotations](https://community.opentargets.org/t/variant-table-and-vep-annotations/1884)
**Author:** [@Ehsan\_Khajouei](https://community.opentargets.org/u/Ehsan_Khajouei)\ **Replies:** 4\ **Last updated:** [1 August 2025 17:21 UTC](https://community.opentargets.org/t/variant-table-and-vep-annotations/1884 "2025-08-01T17:21:29Z")
I want to prioritize variants’ annotation from VEP – from variant table – with the final goal of having only one combination of associated gene/transcript for each variant. The definition of the table columns are not ver… --- ## [Missing Studies in the New Open Targets Release](https://community.opentargets.org/t/missing-studies-in-the-new-open-targets-release/1816)
**Author:** [@BushraDohai](https://community.opentargets.org/u/BushraDohai)\ **Replies:** 5\ **Last updated:** [6 June 2025 09:08 UTC](https://community.opentargets.org/t/missing-studies-in-the-new-open-targets-release/1816 "2025-06-06T09:08:19Z")
Hello Open Targets team, I noticed that in the new release, there are fewer studies available compared to the previous Open Targets Genetics release. Specifically, my dataset included about 11,000 studies from the earli… --- ## [L2G Score in the New Platform: Causality or druggability](https://community.opentargets.org/t/l2g-score-in-the-new-platform-causality-or-druggability/1815)
**Author:** [@BushraDohai](https://community.opentargets.org/u/BushraDohai)\ **Replies:** 2\ **Last updated:** [3 June 2025 13:43 UTC](https://community.opentargets.org/t/l2g-score-in-the-new-platform-causality-or-druggability/1815 "2025-06-03T13:43:25Z")
Hello Open Targets team, I’m working on gene causality analysis and have been using the Open Targets Genetics platform, specifically the L2G (locus-to-gene) score, as a measure of gene causality. In the new release on t… --- ## [Missing variant in Platform compared to Open Targets Genetics](https://community.opentargets.org/t/missing-variant-in-platform-compared-to-open-targets-genetics/1767)
**Author:** [@Stefanie\_Mueller\_BI](https://community.opentargets.org/u/Stefanie_Mueller_BI)\ **Replies:** 5\ **Last updated:** [24 April 2025 11:17 UTC](https://community.opentargets.org/t/missing-variant-in-platform-compared-to-open-targets-genetics/1767 "2025-04-24T11:17:13Z")
Hi Open Targets team, with the new genetics-portal focus on retaining credible set variants only, some discrepancies in variant coverage to the former open targets genetics portal would be expected. Has this been quanti… --- ## [Literature - Disease association error: Papers tagged with "gonorrhea" are really about gastric cancer](https://community.opentargets.org/t/literature-disease-association-error-papers-tagged-with-gonorrhea-are-really-about-gastric-cancer/1453)
**Author:** [@Su\_Mo](https://community.opentargets.org/u/Su_Mo)\ **Replies:** 3\ **Last updated:** [8 April 2025 10:38 UTC](https://community.opentargets.org/t/literature-disease-association-error-papers-tagged-with-gonorrhea-are-really-about-gastric-cancer/1453 "2025-04-08T10:38:14Z")
We observed that many of the papers tagged with gonorrhea are actually about gastric cancer and never mention the word gonorrhea. On a related note, or perhaps as a result, many of the genes associated with gonorrhea ar… --- ## [Clarification on Number of Protein-Coding Drug Targets in OpenTargets Database](https://community.opentargets.org/t/clarification-on-number-of-protein-coding-drug-targets-in-opentargets-database/1722)
**Author:** [@joy2001](https://community.opentargets.org/u/joy2001)\ **Replies:** 1\ **Last updated:** [31 March 2025 13:03 UTC](https://community.opentargets.org/t/clarification-on-number-of-protein-coding-drug-targets-in-opentargets-database/1722 "2025-03-31T13:03:46Z")
Dear OpenTargets Team, I hope this message finds you well. I am currently working on a project where I am focusing on genes for which there is evidence of an interaction between a drug and a gene product, whether suppor… --- ## [Downloadble drug indication data - 'Known drug' vs. 'Drug - indications'](https://community.opentargets.org/t/downloadble-drug-indication-data-known-drug-vs-drug-indications/1735)
**Author:** [@sigven](https://community.opentargets.org/u/sigven)\ **Replies:** 2\ **Last updated:** [31 March 2025 12:44 UTC](https://community.opentargets.org/t/downloadble-drug-indication-data-known-drug-vs-drug-indications/1735 "2025-03-31T12:44:33Z")
Hi, I’ve been looking at the parquet files (25.03 release) from the ‘Known drug’ dataset as well as the ‘Drug - indications’ dataset. I am a bit confused regarding which data to utilize when it comes to drug indication … --- ## [Drug-indication/Clinical precedence pairs on Open Targets](https://community.opentargets.org/t/drug-indication-clinical-precedence-pairs-on-open-targets/1525)
**Author:** [@Uzor](https://community.opentargets.org/u/Uzor)\ **Replies:** 1\ **Last updated:** [13 August 2024 10:42 UTC](https://community.opentargets.org/t/drug-indication-clinical-precedence-pairs-on-open-targets/1525 "2024-08-13T10:42:13Z")
Dear Open Targets team, I need a bit of clarification regarding how the drug-indication/clinical precedence pairs are curated on the platform. The Open Targets documentation states that clinical precedence for drugs are … --- ## [GWAS Catalog results incorporation - backlog or other issue?](https://community.opentargets.org/t/gwas-catalog-results-incorporation-backlog-or-other-issue/1403)
**Author:** [@Joshua\_McElwee](https://community.opentargets.org/u/Joshua_McElwee)\ **Replies:** 2\ **Last updated:** [19 April 2024 14:42 UTC](https://community.opentargets.org/t/gwas-catalog-results-incorporation-backlog-or-other-issue/1403 "2024-04-19T14:42:20Z")
I was looking for GWAS results for a particular SNP for kidney-related phenotypes, and could not find the results in OT for the study (even though the study is in the GWAS catalog). This is a study from 2022 from the Su… --- ## [Bibliography not pulling out association between SOTORASIB and KRAS](https://community.opentargets.org/t/bibliography-not-pulling-out-association-between-sotorasib-and-kras/1394)
**Author:** [@Ellen\_McDonagh](https://community.opentargets.org/u/Ellen_McDonagh)\ **Replies:** 2\ **Last updated:** [10 April 2024 08:28 UTC](https://community.opentargets.org/t/bibliography-not-pulling-out-association-between-sotorasib-and-kras/1394 "2024-04-10T08:28:52Z")
Though SOTORASIB targets KRAS, it seems the bibliography pipeline is not extracting this relationship on either the drug page or gene page that I can see. There are not many publications yet (less than 30 from a quick pu… --- ## [Difference between parquet files and website/API](https://community.opentargets.org/t/difference-between-parquet-files-and-website-api/1349)
**Author:** [@fru](https://community.opentargets.org/u/fru)\ **Replies:** 3\ **Last updated:** [7 February 2024 13:12 UTC](https://community.opentargets.org/t/difference-between-parquet-files-and-website-api/1349 "2024-02-07T13:12:47Z")
Hi, I have downloaded the parquet files for “Associations - direct (by data type)” (Open Targets Platform). I have extracted information for a specific disease (MONDO\_0005277). When I compare the parquet files with the … --- ## [Differences between linkedDiseases and approvedIndications across versions](https://community.opentargets.org/t/differences-between-linkeddiseases-and-approvedindications-across-versions/1330)
**Author:** [@christosasi](https://community.opentargets.org/u/christosasi)\ **Replies:** 0\ **Last updated:** [18 January 2024 17:35 UTC](https://community.opentargets.org/t/differences-between-linkeddiseases-and-approvedindications-across-versions/1330 "2024-01-18T17:35:40Z")
Hi team, I have a query about differences in the ‘molecule’ and ‘indication’ datasets available on OpenTargets. My current understanding of these datasets is according to the schema of the OpenTargets datasets availabl… --- ## [Target Priorisation](https://community.opentargets.org/t/target-priorisation/1195)
**Author:** [@Sean\_Hackett](https://community.opentargets.org/u/Sean_Hackett)\ **Replies:** 5\ **Last updated:** [1 December 2023 10:38 UTC](https://community.opentargets.org/t/target-priorisation/1195 "2023-12-01T10:38:01Z")
Hi folks, I stumbled upon a new table “targetsPriorisation” which seems to have appeared in the 23.06 release (Index of /pub/databases/opentargets/platform/23.06/output/etl/json/targetsPriorisation). I didn’t see any me… --- ## [Difference between variant and gene pages](https://community.opentargets.org/t/difference-between-variant-and-gene-pages/1285)
**Author:** [@tzukuo](https://community.opentargets.org/u/tzukuo)\ **Replies:** 2\ **Last updated:** [23 November 2023 16:26 UTC](https://community.opentargets.org/t/difference-between-variant-and-gene-pages/1285 "2023-11-23T16:26:13Z")
Dear Open Target Community, My study is interested in the association between the variant 6\_41161514\_C\_T and TREM2. The variant’s page suggests a high V2G score, the influential effect, and a short distance between them… --- ## [Strange diseases in downloaded data](https://community.opentargets.org/t/strange-diseases-in-downloaded-data/1284)
**Author:** [@tzukuo](https://community.opentargets.org/u/tzukuo)\ **Replies:** 4\ **Last updated:** [21 November 2023 20:09 UTC](https://community.opentargets.org/t/strange-diseases-in-downloaded-data/1284 "2023-11-21T20:09:59Z")
Dear Open Targets Community, I downloaded OT Genetics data preprocessed by OT Platform to analyze them locally. However, the data include some strange disease descriptions (diseaseFrmSource): While the EFO code mean… --- ## [Duplicated diseases in 22.06](https://community.opentargets.org/t/duplicated-diseases-in-22-06/702)
**Author:** [@ochoa](https://community.opentargets.org/u/ochoa)\ **Replies:** 7\ **Last updated:** [13 March 2023 13:40 UTC](https://community.opentargets.org/t/duplicated-diseases-in-22-06/702 "2023-03-13T13:40:42Z")
Due to a problem in the ontology, a number of rare diseases are duplicated in the 22.06. EFO is currently undergoing a cleanup of the Orphanet terms to assign them to their corresponding MONDO id when appropriate. As par… --- ## [Mismatches between Open Targets Genetics and the GWAS Catalog (Sliz et al. 2021 (GCST90027161))](https://community.opentargets.org/t/mismatches-between-open-targets-genetics-and-the-gwas-catalog-sliz-et-al-2021-gcst90027161/872)
**Author:** [@AleixAS](https://community.opentargets.org/u/AleixAS)\ **Replies:** 2\ **Last updated:** [30 November 2022 18:14 UTC](https://community.opentargets.org/t/mismatches-between-open-targets-genetics-and-the-gwas-catalog-sliz-et-al-2021-gcst90027161/872 "2022-11-30T18:14:29Z")
Dear OTG Team and comunity, I was looking at the reported variants from Sliz et al 2021 (GCST90027161) associated with atopic dermatitis. But, the reported results make no sense to me… The study, as well as GWAS catalo… --- ## [Creating Pandas Dataframe from API POST using Python Requests Function](https://community.opentargets.org/t/creating-pandas-dataframe-from-api-post-using-python-requests-function/816)
**Author:** [@sawagema](https://community.opentargets.org/u/sawagema)\ **Replies:** 6\ **Last updated:** [11 November 2022 23:16 UTC](https://community.opentargets.org/t/creating-pandas-dataframe-from-api-post-using-python-requests-function/816 "2022-11-11T23:16:20Z")
How do I transform the API response from JSON into a pandas dataframe? I am currently looking for drug targets within Alzheimers, here is the post requests script: #gene\_id = "ENSG00000169083" disease\_ids = \["MONDO\_0004… --- ## [Colocalisation status of GWAS study GCST012464 (Mullins et al.)](https://community.opentargets.org/t/colocalisation-status-of-gwas-study-gcst012464-mullins-et-al/740)
**Author:** [@bsg](https://community.opentargets.org/u/bsg)\ **Replies:** 2\ **Last updated:** [26 August 2022 17:30 UTC](https://community.opentargets.org/t/colocalisation-status-of-gwas-study-gcst012464-mullins-et-al/740 "2022-08-26T17:30:00Z")
We had done some colocalisation analysis of our own on the GWAS study of GCST012464 (Bipolar I disorder, Mullins N et al.) and wanted to check it against what OT had for a particular top gene but found that while there w… --- ## [UKB-PPP pQTL data online](https://community.opentargets.org/t/ukb-ppp-pqtl-data-online/670)
**Author:** [@Shicheng\_Guo](https://community.opentargets.org/u/Shicheng_Guo)\ **Replies:** 1\ **Last updated:** [1 July 2022 15:32 UTC](https://community.opentargets.org/t/ukb-ppp-pqtl-data-online/670 "2022-07-01T15:32:59Z")
Dear Team, Exciting UKB-PPP pQTL is online. I am wondering what’s the plan to engage the data to the platform? Do we have a list how many pQTLs have been included in the open targets platform? Thanks. The UK Biobank Ph… --- ## [Mismatched variant consequences between OT Genetics VEP data and the OT Platform evidence page?](https://community.opentargets.org/t/mismatched-variant-consequences-between-ot-genetics-vep-data-and-the-ot-platform-evidence-page/656)
**Author:** [@fedde](https://community.opentargets.org/u/fedde)\ **Replies:** 3\ **Last updated:** [9 June 2022 20:48 UTC](https://community.opentargets.org/t/mismatched-variant-consequences-between-ot-genetics-vep-data-and-the-ot-platform-evidence-page/656 "2022-06-09T20:48:05Z")
The VEP (Ensembl) tab on https://genetics.opentargets.org/variant/1\_169681903\_G\_A lists that, in the gene C1orf112 (ENSG00000000460), that variant’s most severe consequence is that it is intronic. The GWAS lead variants … --- ## [Duplicate genes in the disease-association record with inconsistent scores](https://community.opentargets.org/t/duplicate-genes-in-the-disease-association-record-with-inconsistent-scores/651)
**Author:** [@jasperhyp](https://community.opentargets.org/u/jasperhyp)\ **Replies:** 1\ **Last updated:** [7 June 2022 11:52 UTC](https://community.opentargets.org/t/duplicate-genes-in-the-disease-association-record-with-inconsistent-scores/651 "2022-06-07T11:52:13Z")
Hi, I just want to open a new post to highlight this comment in the other post I created. Basically, there are multiple association records for the same gene, and they do not align well with one another. I am assuming… --- ## [How is ClinVar evidence mapped to disease terms?](https://community.opentargets.org/t/how-is-clinvar-evidence-mapped-to-disease-terms/605)
**Author:** [@SirTarget](https://community.opentargets.org/u/SirTarget)\ **Replies:** 2\ **Last updated:** [20 May 2022 11:59 UTC](https://community.opentargets.org/t/how-is-clinvar-evidence-mapped-to-disease-terms/605 "2022-05-20T11:59:41Z")
For THRB, one of the reported genetic associations is Glycogen storage disease due to glycogen branching enzyme deficiency, an association which is solely supported by ClinVar evidence. However, checking the source reve… --- ## [Drug for anhidrosis](https://community.opentargets.org/t/drug-for-anhidrosis/366)
**Author:** [@Zaki](https://community.opentargets.org/u/Zaki)\ **Replies:** 3\ **Last updated:** [6 October 2021 14:57 UTC](https://community.opentargets.org/t/drug-for-anhidrosis/366 "2021-10-06T14:57:35Z")
Hello Helena/Andrew I watched few videos about Open Target and found them very useful I searched “Anhidrosis” and noticed there is “no data” under “known drugs”. Does this mean there is no specific target to treat anhi… --- ## [CRISPR data score calculation/integration and how about si-shRNA?](https://community.opentargets.org/t/crispr-data-score-calculation-integration-and-how-about-si-shrna/328)
**Author:** [@Nicolas](https://community.opentargets.org/u/Nicolas)\ **Replies:** 1\ **Last updated:** [27 August 2021 15:05 UTC](https://community.opentargets.org/t/crispr-data-score-calculation-integration-and-how-about-si-shrna/328 "2021-08-27T15:05:02Z")
Hi again :blush:, If we understand correctly, the CRISPR data done by the Sanger ‘Score’ project is somehow incorporated in the ‘Pathways & systems biology’ score. Could we have a bit more information about ‘how’ it is … --- ## [Safety data: a specific or incorporated score or an 'information' on target MOA?](https://community.opentargets.org/t/safety-data-a-specific-or-incorporated-score-or-an-information-on-target-moa/325)
**Author:** [@Nicolas](https://community.opentargets.org/u/Nicolas)\ **Replies:** 1\ **Last updated:** [26 August 2021 17:44 UTC](https://community.opentargets.org/t/safety-data-a-specific-or-incorporated-score-or-an-information-on-target-moa/325 "2021-08-26T17:44:51Z")
Dear all, Looking at “Safety data”, how did these data are incorporated ? as we did not find any specific related score (looking at doc it does not seems to be in any score formula) Or maybe it is just a “target informa… --- ## [Target class and "unclassified protein": missing protein class?](https://community.opentargets.org/t/target-class-and-unclassified-protein-missing-protein-class/317)
**Author:** [@Nicolas](https://community.opentargets.org/u/Nicolas)\ **Replies:** 2\ **Last updated:** [19 August 2021 07:00 UTC](https://community.opentargets.org/t/target-class-and-unclassified-protein-missing-protein-class/317 "2021-08-19T07:00:16Z")
Hi , again maybe a trivial question, sorry about that :grinning: (I do have so many…) After doing a search using a disease, you get a certain amount of target (let’s say 10000 for example). If you unfold the “Target c… [Next page](https://community.opentargets.org/c/community-feedback/data-issue/35.md?page=1)