# Community Feedback **URL:** https://community.opentargets.org/c/community-feedback/33.md [Latest](https://community.opentargets.org/latest.md) · [Categories](https://community.opentargets.org/categories.md) · [Tags](https://community.opentargets.org/tags.md) --- ## [About the Community Feedback category](https://community.opentargets.org/t/about-the-community-feedback-category/56)
**Author:** [@community\_manager](https://community.opentargets.org/u/community_manager)\ **Replies:** 1\ **Last updated:** [18 May 2022 01:16 UTC](https://community.opentargets.org/t/about-the-community-feedback-category/56 "2022-05-18T01:16:12Z")
Report bugs and data issues related to either the Open Targets Platform or Open Targets Genetics. --- ## [Column mixed up for tissue specificity and tissue distribution output?](https://community.opentargets.org/t/column-mixed-up-for-tissue-specificity-and-tissue-distribution-output/2069)
**Author:** [@L\_CD](https://community.opentargets.org/u/L_CD)\ **Replies:** 3\ **Last updated:** [24 August 2026 14:18 UTC](https://community.opentargets.org/t/column-mixed-up-for-tissue-specificity-and-tissue-distribution-output/2069 "2026-08-24T14:18:49Z")
Hi tissue\_specificity should have 1, 0.5, 0 , -0.5, -1, NA and tissue\_distribution 1,0.75, 0.5, 0.25,-1, NA values (based on the documentation Target Prioritisation | Open Targets Platform Documentation ). However, in … --- ## [Credible set contains inconsistent NULLs in the locus column](https://community.opentargets.org/t/credible-set-contains-inconsistent-nulls-in-the-locus-column/2056)
**Author:** [@Stepan\_Nersisyan](https://community.opentargets.org/u/Stepan_Nersisyan)\ **Replies:** 3\ **Last updated:** [18 July 2026 15:23 UTC](https://community.opentargets.org/t/credible-set-contains-inconsistent-nulls-in-the-locus-column/2056 "2026-07-18T15:23:12Z")
Hello, I noticed that many credible sets have a problem, where pValueMantissa and pValueExponent columns contain non-NULL values, while when you look up the lead variant in the locus column, you see NULL values despite … --- ## [After 26/6 data download to TSV is broken](https://community.opentargets.org/t/after-26-6-data-download-to-tsv-is-broken/2051)
**Author:** [@panokhin](https://community.opentargets.org/u/panokhin)\ **Replies:** 3\ **Last updated:** [4 July 2026 01:16 UTC](https://community.opentargets.org/t/after-26-6-data-download-to-tsv-is-broken/2051 "2026-07-04T01:16:19Z")
After 26/6 release clicking on Export → Download Data and then choosing TSV results in the page just hanging there forever. I’ve tried multiple diseases, even with small number of targets but none worked. --- ## [Number of target IDs in evidence\_clinical\_precedence for alcohol drinking decreased from 85 to 15 between v26.03 and v26.06](https://community.opentargets.org/t/number-of-target-ids-in-evidence-clinical-precedence-for-alcohol-drinking-decreased-from-85-to-15-between-v26-03-and-v26-06/2048)
**Author:** [@qwang](https://community.opentargets.org/u/qwang)\ **Replies:** 2\ **Last updated:** [2 July 2026 08:54 UTC](https://community.opentargets.org/t/number-of-target-ids-in-evidence-clinical-precedence-for-alcohol-drinking-decreased-from-85-to-15-between-v26-03-and-v26-06/2048 "2026-07-02T08:54:13Z")
Thank you for providing this excellent resource for linking targets, drugs, and indications. I noticed a substantial change in the evidence\_clinical\_precedence table between releases. In v26.03, there were 85 unique tar… --- ## [Weird characters in compound synonym](https://community.opentargets.org/t/weird-characters-in-compound-synonym/2046)
**Author:** [@Tiejun\_Cheng](https://community.opentargets.org/u/Tiejun_Cheng)\ **Replies:** 2\ **Last updated:** [30 June 2026 12:46 UTC](https://community.opentargets.org/t/weird-characters-in-compound-synonym/2046 "2026-06-30T12:46:00Z")
To whom it may concern, I found some weird characters in the compound synonyms, e.g., verorab�0000ae on the following page. Note that you have to click “show more” to see this name. I have seen more cases like this in t… --- ## [Questions regarding the accuracy of data in the Drugs and Clinical Candidates section](https://community.opentargets.org/t/questions-regarding-the-accuracy-of-data-in-the-drugs-and-clinical-candidates-section/2024)
**Author:** [@chen\_lv](https://community.opentargets.org/u/chen_lv)\ **Replies:** 4\ **Last updated:** [19 May 2026 01:37 UTC](https://community.opentargets.org/t/questions-regarding-the-accuracy-of-data-in-the-drugs-and-clinical-candidates-section/2024 "2026-05-19T01:37:52Z")
First of all, I am very grateful for the Open Targets tool, which has brought a lot of convenience to research. When I was searching for drugs related to UC, I found a problem: Aspirin (acetylsalicylic acid) is a classic… --- ## [MGI data not linking through correctly](https://community.opentargets.org/t/mgi-data-not-linking-through-correctly/1955)
**Author:** [@flo](https://community.opentargets.org/u/flo)\ **Replies:** 4\ **Last updated:** [23 March 2026 21:19 UTC](https://community.opentargets.org/t/mgi-data-not-linking-through-correctly/1955 "2026-03-23T21:19:00Z")
Thanks for the excellent 25.12 release! I randomly found that the mouse model evidence information in the target prioritization factor view does not link through to the MGI. For example, for Slc25a13 and the first pheno… --- ## [Lack of approved drug indications](https://community.opentargets.org/t/lack-of-approved-drug-indications/327)
**Author:** [@sigven](https://community.opentargets.org/u/sigven)\ **Replies:** 8\ **Last updated:** [22 September 2025 13:34 UTC](https://community.opentargets.org/t/lack-of-approved-drug-indications/327 "2025-09-22T13:34:19Z")
Hi, I cannot seem to make sense of the indications that are approved for particular drugs (cancer drugs in particular). It seems you now define “approved indication” when an indication is listed for the drug in a clinic… --- ## [Allele alignment issue](https://community.opentargets.org/t/allele-alignment-issue/1925)
**Author:** [@Vince\_Forgetta](https://community.opentargets.org/u/Vince_Forgetta)\ **Replies:** 1\ **Last updated:** [17 September 2025 12:52 UTC](https://community.opentargets.org/t/allele-alignment-issue/1925 "2025-09-17T12:52:02Z")
Hi, Thanks for the wonderful resource! The issue is related to this variant https://platform.opentargets.org/variant/3\_173377333\_A\_G Note the direction of effect of for this credible set is negative for BMI from this … --- ## [ICD-10 Code Issues](https://community.opentargets.org/t/icd-10-code-issues/1926)
**Author:** [@nathand](https://community.opentargets.org/u/nathand)\ **Replies:** 1\ **Last updated:** [17 September 2025 08:11 UTC](https://community.opentargets.org/t/icd-10-code-issues/1926 "2025-09-17T08:11:36Z")
I noticed that on the website, the ICD-10 code for hypertension (https://platform.opentargets.org/disease/EFO\_0000537/associations) appears to be incorrectly listed as O10. Shouldn’t it be I10 instead? (https://icd.who.i… --- ## [Accessing Open Targets Genetics data following deprecation? (finding diseases associated with a SNP)](https://community.opentargets.org/t/accessing-open-targets-genetics-data-following-deprecation-finding-diseases-associated-with-a-snp/1882)
**Author:** [@val5678](https://community.opentargets.org/u/val5678)\ **Replies:** 5\ **Last updated:** [11 September 2025 12:15 UTC](https://community.opentargets.org/t/accessing-open-targets-genetics-data-following-deprecation-finding-diseases-associated-with-a-snp/1882 "2025-09-11T12:15:06Z")
I’m kind of new here. Is there a way to get access to the old open targets platform? For example, I want to select a SNP and look at all the different kinds of cancer associated with it, or look at all the different auto… --- ## [GCS Permission Issue While Running Gentropy Notebook](https://community.opentargets.org/t/gcs-permission-issue-while-running-gentropy-notebook/1909)
**Author:** [@Abdu\_Omar](https://community.opentargets.org/u/Abdu_Omar)\ **Replies:** 6\ **Last updated:** [2 September 2025 19:29 UTC](https://community.opentargets.org/t/gcs-permission-issue-while-running-gentropy-notebook/1909 "2025-09-02T19:29:02Z")
Hi, I am trying to run the FineMapping\_AlzheimerDisease notebook in gentropy repo but I’m encountering a permission error when the code attempts to access GWAS Summary Statistics from Google Cloud Storage. Particularly,… --- ## [Different results when querying disease - case sensitivity](https://community.opentargets.org/t/different-results-when-querying-disease-case-sensitivity/1908)
**Author:** [@ChrisR](https://community.opentargets.org/u/ChrisR)\ **Replies:** 2\ **Last updated:** [26 August 2025 10:24 UTC](https://community.opentargets.org/t/different-results-when-querying-disease-case-sensitivity/1908 "2025-08-26T10:24:46Z")
Hi, I was wondering if this was a data issue? Querying the OT interface for obesity as the disease gives me quite different results from using the query Obesity. The former hit list is much longer, there is incomplete… --- ## [Variant table and VEP annotations](https://community.opentargets.org/t/variant-table-and-vep-annotations/1884)
**Author:** [@Ehsan\_Khajouei](https://community.opentargets.org/u/Ehsan_Khajouei)\ **Replies:** 4\ **Last updated:** [1 August 2025 17:21 UTC](https://community.opentargets.org/t/variant-table-and-vep-annotations/1884 "2025-08-01T17:21:29Z")
I want to prioritize variants’ annotation from VEP – from variant table – with the final goal of having only one combination of associated gene/transcript for each variant. The definition of the table columns are not ver… --- ## [Missing sections in Platform from open targets genetics merge - Assigned Genes and Evidence linking the variant to genes](https://community.opentargets.org/t/missing-sections-in-platform-from-open-targets-genetics-merge-assigned-genes-and-evidence-linking-the-variant-to-genes/1871)
**Author:** [@rosehodgson](https://community.opentargets.org/u/rosehodgson)\ **Replies:** 1\ **Last updated:** [24 July 2025 09:40 UTC](https://community.opentargets.org/t/missing-sections-in-platform-from-open-targets-genetics-merge-assigned-genes-and-evidence-linking-the-variant-to-genes/1871 "2025-07-24T09:40:37Z")
Hi there, I have been using open target genetics to visualise the evidence for association of variants with different genes. I specifically used ot look at the Assigned Genes section which had the tabs, Summary, Distance… --- ## [Snp to gene query](https://community.opentargets.org/t/snp-to-gene-query/1824)
**Author:** [@jsg201717](https://community.opentargets.org/u/jsg201717)\ **Replies:** 2\ **Last updated:** [26 June 2025 00:27 UTC](https://community.opentargets.org/t/snp-to-gene-query/1824 "2025-06-26T00:27:55Z")
Hello, open target genetics is using the function to map the gene for snp by doing a snp to gene query. However, maybe because it was renewed, the old code doesn’t seem to work. Below is a part of the query statement. s… --- ## [OT Platform GWAS credible set issue where there are no L2G predictions \> 0.05— being resolved](https://community.opentargets.org/t/ot-platform-gwas-credible-set-issue-where-there-are-no-l2g-predictions-0-05-being-resolved/1761)
**Author:** [@mjatoi](https://community.opentargets.org/u/mjatoi)\ **Replies:** 4\ **Last updated:** [6 June 2025 10:31 UTC](https://community.opentargets.org/t/ot-platform-gwas-credible-set-issue-where-there-are-no-l2g-predictions-0-05-being-resolved/1761 "2025-06-06T10:31:30Z")
Hi there, I am submitting a bug report for the Open Targets Platform. I searched for a variant and was looking at the GWAS credible set list to find the L2G predictions, but it was not showing up on the webpage and I am… --- ## [Missing Studies in the New Open Targets Release](https://community.opentargets.org/t/missing-studies-in-the-new-open-targets-release/1816)
**Author:** [@BushraDohai](https://community.opentargets.org/u/BushraDohai)\ **Replies:** 5\ **Last updated:** [6 June 2025 09:08 UTC](https://community.opentargets.org/t/missing-studies-in-the-new-open-targets-release/1816 "2025-06-06T09:08:19Z")
Hello Open Targets team, I noticed that in the new release, there are fewer studies available compared to the previous Open Targets Genetics release. Specifically, my dataset included about 11,000 studies from the earli… --- ## [L2G Score in the New Platform: Causality or druggability](https://community.opentargets.org/t/l2g-score-in-the-new-platform-causality-or-druggability/1815)
**Author:** [@BushraDohai](https://community.opentargets.org/u/BushraDohai)\ **Replies:** 2\ **Last updated:** [3 June 2025 13:43 UTC](https://community.opentargets.org/t/l2g-score-in-the-new-platform-causality-or-druggability/1815 "2025-06-03T13:43:25Z")
Hello Open Targets team, I’m working on gene causality analysis and have been using the Open Targets Genetics platform, specifically the L2G (locus-to-gene) score, as a measure of gene causality. In the new release on t… --- ## [Questions about the Open Targets Platform (posterior probability, odds ratio for drug associations, preference for hypothesis-independent genetic data)](https://community.opentargets.org/t/questions-about-the-open-targets-platform-posterior-probability-odds-ratio-for-drug-associations-preference-for-hypothesis-independent-genetic-data/1781)
**Author:** [@Magdalena](https://community.opentargets.org/u/Magdalena)\ **Replies:** 3\ **Last updated:** [15 May 2025 16:18 UTC](https://community.opentargets.org/t/questions-about-the-open-targets-platform-posterior-probability-odds-ratio-for-drug-associations-preference-for-hypothesis-independent-genetic-data/1781 "2025-05-15T16:18:59Z")
For some genetic markers the posterior probability is low but LG2 score is high, they go opposite direction, how to interpret result? I notice that sometimes when I look one variant and then other the part of molQTL r… --- ## [OT web interface - ‘GWAS credible sets’ and ‘molQTL credible sets’ not updating?](https://community.opentargets.org/t/ot-web-interface-gwas-credible-sets-and-molqtl-credible-sets-not-updating/1748)
**Author:** [@ddiogo](https://community.opentargets.org/u/ddiogo)\ **Replies:** 2\ **Last updated:** [15 May 2025 15:14 UTC](https://community.opentargets.org/t/ot-web-interface-gwas-credible-sets-and-molqtl-credible-sets-not-updating/1748 "2025-05-15T15:14:56Z")
Hello, when I open a new OT web page (on chrome), search for a variant, and then search for a second variant, the top of the page updates with the information related to the second variant but the bottom of the page does… --- ## [Missing variant in Platform compared to Open Targets Genetics](https://community.opentargets.org/t/missing-variant-in-platform-compared-to-open-targets-genetics/1767)
**Author:** [@Stefanie\_Mueller\_BI](https://community.opentargets.org/u/Stefanie_Mueller_BI)\ **Replies:** 5\ **Last updated:** [24 April 2025 11:17 UTC](https://community.opentargets.org/t/missing-variant-in-platform-compared-to-open-targets-genetics/1767 "2025-04-24T11:17:13Z")
Hi Open Targets team, with the new genetics-portal focus on retaining credible set variants only, some discrepancies in variant coverage to the former open targets genetics portal would be expected. Has this been quanti… --- ## [Literature - Disease association error: Papers tagged with "gonorrhea" are really about gastric cancer](https://community.opentargets.org/t/literature-disease-association-error-papers-tagged-with-gonorrhea-are-really-about-gastric-cancer/1453)
**Author:** [@Su\_Mo](https://community.opentargets.org/u/Su_Mo)\ **Replies:** 3\ **Last updated:** [8 April 2025 10:38 UTC](https://community.opentargets.org/t/literature-disease-association-error-papers-tagged-with-gonorrhea-are-really-about-gastric-cancer/1453 "2025-04-08T10:38:14Z")
We observed that many of the papers tagged with gonorrhea are actually about gastric cancer and never mention the word gonorrhea. On a related note, or perhaps as a result, many of the genes associated with gonorrhea ar… --- ## [Clarification on Number of Protein-Coding Drug Targets in OpenTargets Database](https://community.opentargets.org/t/clarification-on-number-of-protein-coding-drug-targets-in-opentargets-database/1722)
**Author:** [@joy2001](https://community.opentargets.org/u/joy2001)\ **Replies:** 1\ **Last updated:** [31 March 2025 13:03 UTC](https://community.opentargets.org/t/clarification-on-number-of-protein-coding-drug-targets-in-opentargets-database/1722 "2025-03-31T13:03:46Z")
Dear OpenTargets Team, I hope this message finds you well. I am currently working on a project where I am focusing on genes for which there is evidence of an interaction between a drug and a gene product, whether suppor… --- ## [Downloadble drug indication data - 'Known drug' vs. 'Drug - indications'](https://community.opentargets.org/t/downloadble-drug-indication-data-known-drug-vs-drug-indications/1735)
**Author:** [@sigven](https://community.opentargets.org/u/sigven)\ **Replies:** 2\ **Last updated:** [31 March 2025 12:44 UTC](https://community.opentargets.org/t/downloadble-drug-indication-data-known-drug-vs-drug-indications/1735 "2025-03-31T12:44:33Z")
Hi, I’ve been looking at the parquet files (25.03 release) from the ‘Known drug’ dataset as well as the ‘Drug - indications’ dataset. I am a bit confused regarding which data to utilize when it comes to drug indication … --- ## [proteinIds column all empty in parquet file?](https://community.opentargets.org/t/proteinids-column-all-empty-in-parquet-file/1731)
**Author:** [@need47](https://community.opentargets.org/u/need47)\ **Replies:** 2\ **Last updated:** [29 March 2025 11:04 UTC](https://community.opentargets.org/t/proteinids-column-all-empty-in-parquet-file/1731 "2025-03-29T11:04:44Z")
I think the proteinIds column in all the parquet files in the following location are empty: I use the Python’s fastparquet and pandas packages to parse the parquet files. Could you please double check? Tiejun Cheng --- ## [Summary stats used from Bellenguez et al AD GWAS - stage 1 vs meta?](https://community.opentargets.org/t/summary-stats-used-from-bellenguez-et-al-ad-gwas-stage-1-vs-meta/1719)
**Author:** [@loomiss1](https://community.opentargets.org/u/loomiss1)\ **Replies:** 2\ **Last updated:** [27 March 2025 13:03 UTC](https://community.opentargets.org/t/summary-stats-used-from-bellenguez-et-al-ad-gwas-stage-1-vs-meta/1719 "2025-03-27T13:03:17Z")
Hi there, I was looking at the results for a specific study - the 2022 AD GWAS by Bellenguez et al and noticed that one of the significant results from the stage 1 + stage 2 meta analysis wasn’t present (SORT1, on chrom… --- ## [Uploading list of target \_advanced\_filte](https://community.opentargets.org/t/uploading-list-of-target-advanced-filte/1714)
**Author:** [@cbattaglia](https://community.opentargets.org/u/cbattaglia)\ **Replies:** 1\ **Last updated:** [24 March 2025 10:18 UTC](https://community.opentargets.org/t/uploading-list-of-target-advanced-filte/1714 "2025-03-24T10:18:55Z")
Dear Technical support, I would like to explore if targets are included in the associated targets with a disease. I have tried the use of advanced filter but using a TXT files with gene symbols. The system is not rec… --- ## [Incoherency between score in a disease page and a gene page](https://community.opentargets.org/t/incoherency-between-score-in-a-disease-page-and-a-gene-page/1676)
**Author:** [@Aner\_Ottolenghi](https://community.opentargets.org/u/Aner_Ottolenghi)\ **Replies:** 4\ **Last updated:** [24 February 2025 14:12 UTC](https://community.opentargets.org/t/incoherency-between-score-in-a-disease-page-and-a-gene-page/1676 "2025-02-24T14:12:49Z")
When I was looking on the association of ITGA4 and autoimmune disease, I get a different score depending on whether I’m looking in the gene page or disease page [Next page](https://community.opentargets.org/c/community-feedback/33.md?page=1)